Antibody Humanization Methods for Development of Therapeutic Applications

Recombinant antibody technologies are rapidly becoming available and showing considerable clinical success. However, the immunogenicity of murine-derived monoclonal antibodies is restrictive in cancer immunotherapy. Humanized antibodies can overcome these problems and are considered to be a promisin...

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Veröffentlicht in:	Monoclonal antibodies in immunodiagnosis and immunotherapy 2014-04, Vol.33 (2), p.67-73
Hauptverfasser:	Ahmadzadeh, Vahideh, Farajnia, Safar, Feizi, Mohammad Ali Hosseinpour, Nejad, Ramezan Ali Khavari
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Antibodies, Monoclonal, Humanized - biosynthesis Antibodies, Monoclonal, Humanized - genetics Antibodies, Monoclonal, Humanized - therapeutic use Antineoplastic Agents - therapeutic use Complementarity Determining Regions - biosynthesis Complementarity Determining Regions - genetics Humans Protein Engineering - methods Review Article
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Beschreibung
Zusammenfassung:	Recombinant antibody technologies are rapidly becoming available and showing considerable clinical success. However, the immunogenicity of murine-derived monoclonal antibodies is restrictive in cancer immunotherapy. Humanized antibodies can overcome these problems and are considered to be a promising alternative therapeutic agent. There are several approaches for antibody humanization. In this article we review various methods used in the antibody humanization process.
ISSN:	2167-9436 2167-9436
DOI:	10.1089/mab.2013.0080