Neuroprotection by valproic acid in an intrastriatal rotenone model of Parkinson’s disease

Highlights • A novel three-point intrastriatal rotenone rat model of Parkinson’s disease was used. • Chronic treatment with valproic acid abolished forelimb motor dysfunction in this model. • Valproic acid also blocked the loss of dopamine neurons in the substantia nigra. • First evidence of neuropr...

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Veröffentlicht in:	Neuroscience 2014-05, Vol.267, p.114-121
Hauptverfasser:	Carriere, C.H, Kang, N.H, Niles, L.P
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Dopaminergic Neurons - pathology Functional Laterality Insecticides - toxicity intrastriatal Male Medical sciences Neurology Neuropharmacology neuroprotection Neuroprotective Agents - blood Neuroprotective Agents - therapeutic use Parkinson Disease - blood Parkinson Disease - complications Parkinson Disease - drug therapy Parkinson Disease - etiology Parkinson’s disease Pharmacology. Drug treatments Postural Balance - drug effects Rats Rats, Sprague-Dawley rotenone Rotenone - toxicity Sensation Disorders - drug therapy Substantia Nigra - pathology Time Factors Tyrosine 3-Monooxygenase - metabolism valproic acid Valproic Acid - blood Valproic Acid - therapeutic use
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Zusammenfassung:	Highlights • A novel three-point intrastriatal rotenone rat model of Parkinson’s disease was used. • Chronic treatment with valproic acid abolished forelimb motor dysfunction in this model. • Valproic acid also blocked the loss of dopamine neurons in the substantia nigra. • First evidence of neuroprotection by valproic acid in an intracranial rotenone model.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.02.028