Relationship between Insulin-Like Growth Factor I Levels, Early Insulin Treatment, and Clinical Outcomes of Very Low Birth Weight Infants
Objectives Insulin regulates the secretion of insulin-like growth factor I (IGF-I) in the newborn, and low levels of IGF-I have been linked to neonatal morbidity. As part of the Neonatal Insulin Replacement Therapy in Europe Trial, we investigated the impact of early insulin treatment on IGF-I level...
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| creator | Beardsall, Kathryn, FRCPCH Vanhaesebrouck, Sophie, PhD Frystyk, Jan, MD, PhD, DMSc Ogilvy-Stuart, Amanda L., FRCP Vanhole, Christine, PhD van Weissenbruch, Mirjam, PhD Midgley, Paula, FRCPCH Thio, Marta, MD Cornette, Luc, MD Gill, Bryan, FRCPCH Ossuetta, Iviano, FRCPCH Iglesias, Isabel, MD Theyskens, Claire, MD de Jong, Miranda, MD Ahluwalia, Jag S., FRCPCH de Zegher, Francis, PhD Dunger, David B., MD, FMed Sci |
| description | Objectives Insulin regulates the secretion of insulin-like growth factor I (IGF-I) in the newborn, and low levels of IGF-I have been linked to neonatal morbidity. As part of the Neonatal Insulin Replacement Therapy in Europe Trial, we investigated the impact of early insulin treatment on IGF-I levels and their relationship with morbidity and growth. Study design Prospective cohort analyses of data collected as part of an international randomized controlled trial. Blood samples (days 1, 3, 7, and 28), were taken for IGF-I bioassay from 283 very low birth weight infants ( |
| doi_str_mv | 10.1016/j.jpeds.2013.12.046 |
| format | Article |
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As part of the Neonatal Insulin Replacement Therapy in Europe Trial, we investigated the impact of early insulin treatment on IGF-I levels and their relationship with morbidity and growth. Study design Prospective cohort analyses of data collected as part of an international randomized controlled trial. Blood samples (days 1, 3, 7, and 28), were taken for IGF-I bioassay from 283 very low birth weight infants (<1500 g). Results Early insulin treatment led to a late increase in IGF-I levels between day 7 and 28 ( P = .028). In the first week of life IGF-I levels were lower in infants with early hyperglycemia; mean difference −0.10 μg/L (95% CI −0.19, −0.02, P = .02). Lower levels of IGF-I at day 28 were independently associated with an increased risk of chronic lung disease, OR 3.23 (95% CI, 1.09-9.10), and greater IGF-I levels were independently associated with better weight gain, 0.10 kg (95% CI, 0.03-0.33, P = .02). Conclusions Early intervention with insulin is related to increased IGF-I levels at 28 days. Low IGF-I levels are associated with hyperglycemia, increased morbidity, and reduced growth. Increasing IGF-I levels may improve outcomes of very low birth weight infants.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2013.12.046</identifier><identifier>PMID: 24518169</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Biomarkers - metabolism ; Blood Glucose - metabolism ; Drug Administration Schedule ; Female ; Humans ; Hyperglycemia - blood ; Hyperglycemia - prevention & control ; Hypoglycemic Agents - therapeutic use ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases - blood ; Infant, Premature, Diseases - prevention & control ; Infant, Very Low Birth Weight - blood ; Insulin - therapeutic use ; Insulin-Like Growth Factor I - metabolism ; Intention to Treat Analysis ; Linear Models ; Lung Diseases, Obstructive - blood ; Lung Diseases, Obstructive - etiology ; Lung Diseases, Obstructive - prevention & control ; Male ; Pediatrics ; Prospective Studies ; Treatment Outcome ; Weight Gain</subject><ispartof>The Journal of pediatrics, 2014-05, Vol.164 (5), p.1038-1044.e1</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-bcf38db464d863e8eaddfd86fa0138018c7391278bfc5b11384927eebae010933</citedby><cites>FETCH-LOGICAL-c414t-bcf38db464d863e8eaddfd86fa0138018c7391278bfc5b11384927eebae010933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022347613015928$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24518169$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beardsall, Kathryn, FRCPCH</creatorcontrib><creatorcontrib>Vanhaesebrouck, Sophie, PhD</creatorcontrib><creatorcontrib>Frystyk, Jan, MD, PhD, DMSc</creatorcontrib><creatorcontrib>Ogilvy-Stuart, Amanda L., FRCP</creatorcontrib><creatorcontrib>Vanhole, Christine, PhD</creatorcontrib><creatorcontrib>van Weissenbruch, Mirjam, PhD</creatorcontrib><creatorcontrib>Midgley, Paula, FRCPCH</creatorcontrib><creatorcontrib>Thio, Marta, MD</creatorcontrib><creatorcontrib>Cornette, Luc, MD</creatorcontrib><creatorcontrib>Gill, Bryan, FRCPCH</creatorcontrib><creatorcontrib>Ossuetta, Iviano, FRCPCH</creatorcontrib><creatorcontrib>Iglesias, Isabel, MD</creatorcontrib><creatorcontrib>Theyskens, Claire, MD</creatorcontrib><creatorcontrib>de Jong, Miranda, MD</creatorcontrib><creatorcontrib>Ahluwalia, Jag S., FRCPCH</creatorcontrib><creatorcontrib>de Zegher, Francis, PhD</creatorcontrib><creatorcontrib>Dunger, David B., MD, FMed Sci</creatorcontrib><creatorcontrib>NIRTURE Study Group</creatorcontrib><title>Relationship between Insulin-Like Growth Factor I Levels, Early Insulin Treatment, and Clinical Outcomes of Very Low Birth Weight Infants</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Objectives Insulin regulates the secretion of insulin-like growth factor I (IGF-I) in the newborn, and low levels of IGF-I have been linked to neonatal morbidity. As part of the Neonatal Insulin Replacement Therapy in Europe Trial, we investigated the impact of early insulin treatment on IGF-I levels and their relationship with morbidity and growth. Study design Prospective cohort analyses of data collected as part of an international randomized controlled trial. Blood samples (days 1, 3, 7, and 28), were taken for IGF-I bioassay from 283 very low birth weight infants (<1500 g). Results Early insulin treatment led to a late increase in IGF-I levels between day 7 and 28 ( P = .028). In the first week of life IGF-I levels were lower in infants with early hyperglycemia; mean difference −0.10 μg/L (95% CI −0.19, −0.02, P = .02). Lower levels of IGF-I at day 28 were independently associated with an increased risk of chronic lung disease, OR 3.23 (95% CI, 1.09-9.10), and greater IGF-I levels were independently associated with better weight gain, 0.10 kg (95% CI, 0.03-0.33, P = .02). Conclusions Early intervention with insulin is related to increased IGF-I levels at 28 days. Low IGF-I levels are associated with hyperglycemia, increased morbidity, and reduced growth. Increasing IGF-I levels may improve outcomes of very low birth weight infants.</description><subject>Biomarkers - metabolism</subject><subject>Blood Glucose - metabolism</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperglycemia - blood</subject><subject>Hyperglycemia - prevention & control</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Premature, Diseases - blood</subject><subject>Infant, Premature, Diseases - prevention & control</subject><subject>Infant, Very Low Birth Weight - blood</subject><subject>Insulin - therapeutic use</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Intention to Treat Analysis</subject><subject>Linear Models</subject><subject>Lung Diseases, Obstructive - blood</subject><subject>Lung Diseases, Obstructive - etiology</subject><subject>Lung Diseases, Obstructive - prevention & control</subject><subject>Male</subject><subject>Pediatrics</subject><subject>Prospective Studies</subject><subject>Treatment Outcome</subject><subject>Weight Gain</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks1u1DAUhS0EokPhCZCQlyya4Bvnx1mABKO2jBSpEhRYWo5zwzjNxFPb6WgegbfGw0xZsGFl6-qcc6XvXEJeA0uBQfluSIctdj7NGPAUspTl5ROyAFZXSSk4f0oWjGVZwvOqPCMvvB8YY3XO2HNyluUFCCjrBfn1BUcVjJ382mxpi2GHONHV5OfRTElj7pBeO7sLa3qldLCOrmiDDzj6C3qp3Lh_lNJbhypscAoXVE0dXcaZ0WqkN3PQdoOe2p5-R7enjd3RT8bFxB9ofq5DTOjVFPxL8qxXo8dXp_ecfLu6vF1-Tpqb69XyY5PoHPKQtLrnomvzMu9EyVGg6ro-fnsVMQgGQle8hqwSba-LFuIsr7MKsVXIIhvOz8nbY-7W2fsZfZAb4zWOo5rQzl5CAZUQwIs6SvlRqp313mEvt85slNtLYPLQgRzknw7koQMJmYwdRNeb04K53WD31_MIPQreHwURIz4YdNJrg5PGzjjUQXbW_GfBh3_8-kT7DvfoBzu7KRKUIH00yK-HMzhcAXAGRZ0J_hv_aK66</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Beardsall, Kathryn, FRCPCH</creator><creator>Vanhaesebrouck, Sophie, PhD</creator><creator>Frystyk, Jan, MD, PhD, DMSc</creator><creator>Ogilvy-Stuart, Amanda L., FRCP</creator><creator>Vanhole, Christine, PhD</creator><creator>van Weissenbruch, Mirjam, PhD</creator><creator>Midgley, Paula, FRCPCH</creator><creator>Thio, Marta, MD</creator><creator>Cornette, Luc, MD</creator><creator>Gill, Bryan, FRCPCH</creator><creator>Ossuetta, Iviano, FRCPCH</creator><creator>Iglesias, Isabel, MD</creator><creator>Theyskens, Claire, MD</creator><creator>de Jong, Miranda, MD</creator><creator>Ahluwalia, Jag S., FRCPCH</creator><creator>de Zegher, Francis, PhD</creator><creator>Dunger, David B., MD, FMed Sci</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140501</creationdate><title>Relationship between Insulin-Like Growth Factor I Levels, Early Insulin Treatment, and Clinical Outcomes of Very Low Birth Weight Infants</title><author>Beardsall, Kathryn, FRCPCH ; Vanhaesebrouck, Sophie, PhD ; Frystyk, Jan, MD, PhD, DMSc ; Ogilvy-Stuart, Amanda L., FRCP ; Vanhole, Christine, PhD ; van Weissenbruch, Mirjam, PhD ; Midgley, Paula, FRCPCH ; Thio, Marta, MD ; Cornette, Luc, MD ; Gill, Bryan, FRCPCH ; Ossuetta, Iviano, FRCPCH ; Iglesias, Isabel, MD ; Theyskens, Claire, MD ; de Jong, Miranda, MD ; Ahluwalia, Jag S., FRCPCH ; de Zegher, Francis, PhD ; Dunger, David B., MD, FMed Sci</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-bcf38db464d863e8eaddfd86fa0138018c7391278bfc5b11384927eebae010933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Biomarkers - metabolism</topic><topic>Blood Glucose - metabolism</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperglycemia - blood</topic><topic>Hyperglycemia - prevention & control</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infant, Premature, Diseases - blood</topic><topic>Infant, Premature, Diseases - prevention & control</topic><topic>Infant, Very Low Birth Weight - blood</topic><topic>Insulin - therapeutic use</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Intention to Treat Analysis</topic><topic>Linear Models</topic><topic>Lung Diseases, Obstructive - blood</topic><topic>Lung Diseases, Obstructive - etiology</topic><topic>Lung Diseases, Obstructive - prevention & control</topic><topic>Male</topic><topic>Pediatrics</topic><topic>Prospective Studies</topic><topic>Treatment Outcome</topic><topic>Weight Gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beardsall, Kathryn, FRCPCH</creatorcontrib><creatorcontrib>Vanhaesebrouck, Sophie, PhD</creatorcontrib><creatorcontrib>Frystyk, Jan, MD, PhD, DMSc</creatorcontrib><creatorcontrib>Ogilvy-Stuart, Amanda L., FRCP</creatorcontrib><creatorcontrib>Vanhole, Christine, PhD</creatorcontrib><creatorcontrib>van Weissenbruch, Mirjam, PhD</creatorcontrib><creatorcontrib>Midgley, Paula, FRCPCH</creatorcontrib><creatorcontrib>Thio, Marta, MD</creatorcontrib><creatorcontrib>Cornette, Luc, MD</creatorcontrib><creatorcontrib>Gill, Bryan, FRCPCH</creatorcontrib><creatorcontrib>Ossuetta, Iviano, FRCPCH</creatorcontrib><creatorcontrib>Iglesias, Isabel, MD</creatorcontrib><creatorcontrib>Theyskens, Claire, MD</creatorcontrib><creatorcontrib>de Jong, Miranda, MD</creatorcontrib><creatorcontrib>Ahluwalia, Jag S., FRCPCH</creatorcontrib><creatorcontrib>de Zegher, Francis, PhD</creatorcontrib><creatorcontrib>Dunger, David B., MD, FMed Sci</creatorcontrib><creatorcontrib>NIRTURE Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beardsall, Kathryn, FRCPCH</au><au>Vanhaesebrouck, Sophie, PhD</au><au>Frystyk, Jan, MD, PhD, DMSc</au><au>Ogilvy-Stuart, Amanda L., FRCP</au><au>Vanhole, Christine, PhD</au><au>van Weissenbruch, Mirjam, PhD</au><au>Midgley, Paula, FRCPCH</au><au>Thio, Marta, MD</au><au>Cornette, Luc, MD</au><au>Gill, Bryan, FRCPCH</au><au>Ossuetta, Iviano, FRCPCH</au><au>Iglesias, Isabel, MD</au><au>Theyskens, Claire, MD</au><au>de Jong, Miranda, MD</au><au>Ahluwalia, Jag S., FRCPCH</au><au>de Zegher, Francis, PhD</au><au>Dunger, David B., MD, FMed Sci</au><aucorp>NIRTURE Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between Insulin-Like Growth Factor I Levels, Early Insulin Treatment, and Clinical Outcomes of Very Low Birth Weight Infants</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>164</volume><issue>5</issue><spage>1038</spage><epage>1044.e1</epage><pages>1038-1044.e1</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><abstract>Objectives Insulin regulates the secretion of insulin-like growth factor I (IGF-I) in the newborn, and low levels of IGF-I have been linked to neonatal morbidity. As part of the Neonatal Insulin Replacement Therapy in Europe Trial, we investigated the impact of early insulin treatment on IGF-I levels and their relationship with morbidity and growth. Study design Prospective cohort analyses of data collected as part of an international randomized controlled trial. Blood samples (days 1, 3, 7, and 28), were taken for IGF-I bioassay from 283 very low birth weight infants (<1500 g). Results Early insulin treatment led to a late increase in IGF-I levels between day 7 and 28 ( P = .028). In the first week of life IGF-I levels were lower in infants with early hyperglycemia; mean difference −0.10 μg/L (95% CI −0.19, −0.02, P = .02). Lower levels of IGF-I at day 28 were independently associated with an increased risk of chronic lung disease, OR 3.23 (95% CI, 1.09-9.10), and greater IGF-I levels were independently associated with better weight gain, 0.10 kg (95% CI, 0.03-0.33, P = .02). Conclusions Early intervention with insulin is related to increased IGF-I levels at 28 days. Low IGF-I levels are associated with hyperglycemia, increased morbidity, and reduced growth. Increasing IGF-I levels may improve outcomes of very low birth weight infants.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24518169</pmid><doi>10.1016/j.jpeds.2013.12.046</doi></addata></record> |
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| ispartof | The Journal of pediatrics, 2014-05, Vol.164 (5), p.1038-1044.e1 |
| issn | 0022-3476 1097-6833 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Biomarkers - metabolism Blood Glucose - metabolism Drug Administration Schedule Female Humans Hyperglycemia - blood Hyperglycemia - prevention & control Hypoglycemic Agents - therapeutic use Infant, Newborn Infant, Premature Infant, Premature, Diseases - blood Infant, Premature, Diseases - prevention & control Infant, Very Low Birth Weight - blood Insulin - therapeutic use Insulin-Like Growth Factor I - metabolism Intention to Treat Analysis Linear Models Lung Diseases, Obstructive - blood Lung Diseases, Obstructive - etiology Lung Diseases, Obstructive - prevention & control Male Pediatrics Prospective Studies Treatment Outcome Weight Gain |
| title | Relationship between Insulin-Like Growth Factor I Levels, Early Insulin Treatment, and Clinical Outcomes of Very Low Birth Weight Infants |
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