Relationship between Insulin-Like Growth Factor I Levels, Early Insulin Treatment, and Clinical Outcomes of Very Low Birth Weight Infants

Objectives Insulin regulates the secretion of insulin-like growth factor I (IGF-I) in the newborn, and low levels of IGF-I have been linked to neonatal morbidity. As part of the Neonatal Insulin Replacement Therapy in Europe Trial, we investigated the impact of early insulin treatment on IGF-I level...

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Veröffentlicht in:	The Journal of pediatrics 2014-05, Vol.164 (5), p.1038-1044.e1
Hauptverfasser:	Beardsall, Kathryn, FRCPCH, Vanhaesebrouck, Sophie, PhD, Frystyk, Jan, MD, PhD, DMSc, Ogilvy-Stuart, Amanda L., FRCP, Vanhole, Christine, PhD, van Weissenbruch, Mirjam, PhD, Midgley, Paula, FRCPCH, Thio, Marta, MD, Cornette, Luc, MD, Gill, Bryan, FRCPCH, Ossuetta, Iviano, FRCPCH, Iglesias, Isabel, MD, Theyskens, Claire, MD, de Jong, Miranda, MD, Ahluwalia, Jag S., FRCPCH, de Zegher, Francis, PhD, Dunger, David B., MD, FMed Sci
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers - metabolism Blood Glucose - metabolism Drug Administration Schedule Female Humans Hyperglycemia - blood Hyperglycemia - prevention & control Hypoglycemic Agents - therapeutic use Infant, Newborn Infant, Premature Infant, Premature, Diseases - blood Infant, Premature, Diseases - prevention & control Infant, Very Low Birth Weight - blood Insulin - therapeutic use Insulin-Like Growth Factor I - metabolism Intention to Treat Analysis Linear Models Lung Diseases, Obstructive - blood Lung Diseases, Obstructive - etiology Lung Diseases, Obstructive - prevention & control Male Pediatrics Prospective Studies Treatment Outcome Weight Gain
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Zusammenfassung:	Objectives Insulin regulates the secretion of insulin-like growth factor I (IGF-I) in the newborn, and low levels of IGF-I have been linked to neonatal morbidity. As part of the Neonatal Insulin Replacement Therapy in Europe Trial, we investigated the impact of early insulin treatment on IGF-I levels and their relationship with morbidity and growth. Study design Prospective cohort analyses of data collected as part of an international randomized controlled trial. Blood samples (days 1, 3, 7, and 28), were taken for IGF-I bioassay from 283 very low birth weight infants (
ISSN:	0022-3476 1097-6833
DOI:	10.1016/j.jpeds.2013.12.046