Calorie restriction attenuates lipopolysaccharide (LPS)-induced microglial activation in discrete regions of the hypothalamus and the subfornical organ

Calorie restriction attenuates lipopolysaccharide (LPS)-induced microglial activation in discrete regions of the hypothalamus and the subfornical organ

Highlights • Calorie restriction blocks LPS-induced fever and attenuates LPS-induced microglial activation in the hypothalamus and subfornical organ.

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Bibliographische Detailangaben
Veröffentlicht in:Brain, behavior, and immunity behavior, and immunity, 2014-05, Vol.38, p.13-24
Hauptverfasser: Radler, Morgan E, Hale, Matthew W, Kent, Stephen
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Animals
Calcium-Binding Proteins - metabolism
Caloric Restriction
Hypothalamus - drug effects
Hypothalamus - metabolism
Lipopolysaccharides - pharmacology
Male
Mice
Mice, Inbred C57BL
Microfilament Proteins - metabolism
Microglia - drug effects
Microglia - metabolism
Psychiatry
Subfornical Organ - drug effects
Subfornical Organ - metabolism
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Beschreibung
Zusammenfassung:Highlights • Calorie restriction blocks LPS-induced fever and attenuates LPS-induced microglial activation in the hypothalamus and subfornical organ.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2013.11.014