Linkage relationships and gene order around the locus for X-linked retinoschisis

Linkage relationships and gene order around the locus for X-linked retinoschisis

X-linked recessive retinoschisis (RS) is a hereditary disorder with variable clinical features. The authors used nine polymorphic DNA markers to study the localization of RS on the short arm of the X chromosome in 31 families comprising 88 affected persons. Two-point linkage results confirmed close...

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Veröffentlicht in:Human genetics 1988-01, Vol.43 (4), p.476-483
Hauptverfasser: Alitalo, T, sius, H, Kaarnaa, J, Frants, R R, Eriksson, A W, Wood, S, Kruse, T A, de la Chapelle, A
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Sprache:eng
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Zusammenfassung:X-linked recessive retinoschisis (RS) is a hereditary disorder with variable clinical features. The authors used nine polymorphic DNA markers to study the localization of RS on the short arm of the X chromosome in 31 families comprising 88 affected persons. Two-point linkage results confirmed close linkage of the RS gene to the marker loci DXS43, DXS16, DXS207, and DXS41 and also revealed close linkage to the marker loci DXS197 and DXS9.
ISSN:0340-6717