Safety of 13-valent pneumococcal conjugate vaccine in infants and children: Meta-analysis of 13 clinical trials in 9 countries

Highlights • Safety meta-analyses enable detection of rare safety events. • PCV7 has a well-known safety profile based on 10 years clinical experience. • Across 13 clinical trials PCV13 demonstrated a safety profile similar to PCV7.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2013-10, Vol.31 (45), p.5289-5295
Hauptverfasser:	Thompson, Allison, Gurtman, Alejandra, Patterson, Scott, Juergens, Christine, Laudat, France, Emini, Emilio A, Gruber, William C, Scott, Daniel A
Format:	Artikel
Sprache:	eng
Schlagworte:	13-Valent pneumococcal conjugate vaccine Adverse events Allergy and Immunology appetite Applied microbiology Asia Bacteriology Biological and medical sciences Child, Preschool children Children & youth Clinical trials Clinical Trials as Topic Drug-Related Side Effects and Adverse Reactions - epidemiology Drug-Related Side Effects and Adverse Reactions - pathology Europe Female fever Fundamental and applied biological sciences. Psychology Heptavalent Pneumococcal Conjugate Vaccine Humans Immunization Infant Infants injection site Lymphatic system Male Meta-analysis Microbiology Miscellaneous Mortality North America Pneumococcal Vaccines - administration & dosage Pneumococcal Vaccines - adverse effects Pneumonia Preschool children Safety sleep deprivation Streptococcus infections Streptococcus pneumoniae Studies toddlers Vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Conjugate - administration & dosage Vaccines, Conjugate - adverse effects
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Beschreibung
Zusammenfassung:	Highlights • Safety meta-analyses enable detection of rare safety events. • PCV7 has a well-known safety profile based on 10 years clinical experience. • Across 13 clinical trials PCV13 demonstrated a safety profile similar to PCV7.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.08.025