Risks and safety of pandemic h1n1 influenza vaccine in pregnancy: Birth defects, spontaneous abortion, preterm delivery, and small for gestational age infants

Highlights • Information is needed on safety of pandemic H1N1 influenza vaccines in pregnancy. • 1032 exposed pregnant women were followed to pregnancy outcome, 2009–2012. • No increases in birth defects, spontaneous abortion or growth restriction were seen. • Vaccinated women on average delivered 3...

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Veröffentlicht in:	Vaccine 2013-10, Vol.31 (44), p.5026-5032
Hauptverfasser:	Chambers, Christina D, Johnson, Diana, Xu, Ronghui, Luo, Yunjun, Louik, Carol, Mitchell, Allen A, Schatz, Michael, Jones, Kenneth L
Format:	Artikel
Sprache:	eng
Schlagworte:	Abortion Abortion, Spontaneous - epidemiology Adult Allergy and Immunology Applied microbiology Biological and medical sciences Birth defects Canada Congenital Abnormalities - epidemiology Epidemiological Monitoring Exposure Female Fetuses Fundamental and applied biological sciences. Psychology Humans Immunization Infant, Newborn Infant, Small for Gestational Age Infants Influenza A Virus, H1N1 Subtype Influenza Vaccines - administration & dosage Influenza Vaccines - adverse effects Influenza, Human - prevention & control Interviews Microbiology Miscellaneous Pandemic H1N1 influenza vaccination Pandemics Pregnancy Premature Birth - epidemiology Preterm delivery Prospective Studies Risk Risk assessment Safety Small for gestational age Spontaneous abortion Studies Swine flu United States Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Virology
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Beschreibung
Zusammenfassung:	Highlights • Information is needed on safety of pandemic H1N1 influenza vaccines in pregnancy. • 1032 exposed pregnant women were followed to pregnancy outcome, 2009–2012. • No increases in birth defects, spontaneous abortion or growth restriction were seen. • Vaccinated women on average delivered 3 days earlier than non-vaccinated. • This study adds to the reassuring literature about pH1N1 vaccines in pregnancy.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.08.097