New attenuated vaccine against columnaris disease in fish: Choosing the right parental strain is critical for vaccine efficacy

Highlights • Columnaris vaccine efficacy is related to the genetics of the avirulent mutants. • Genomovar II vaccines better prevent columnaris disease. • Avirulent mutant, 17-23, was identified as the best vaccine candidate.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2013-10, Vol.31 (45), p.5276-5280
Hauptverfasser:	Mohammed, Haitham, Olivares-Fuster, Oscar, LaFrentz, Stacey, Arias, Covadonga R
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Bacterial Vaccines - administration & dosage Bacterial Vaccines - immunology Bacteriology Biological and medical sciences Catfish Cichlids Columnaris disease Danio rerio fingerlings Fish Fish diseases Fish Diseases - immunology Fish Diseases - prevention & control fish fry Flavobacteriaceae Infections - immunology Flavobacteriaceae Infections - prevention & control Flavobacteriaceae Infections - veterinary Flavobacterium - genetics Flavobacterium - immunology Flavobacterium columnare Fundamental and applied biological sciences. Psychology Genotype Ictaluridae Ictalurus punctatus Immunization Medical research Microbiology Mortality Mutants Oreochromis niloticus Species diversity Survival Analysis Tilapia vaccination Vaccine Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - immunology virulence Zebrafish
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Beschreibung
Zusammenfassung:	Highlights • Columnaris vaccine efficacy is related to the genetics of the avirulent mutants. • Genomovar II vaccines better prevent columnaris disease. • Avirulent mutant, 17-23, was identified as the best vaccine candidate.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.08.052