Hepatitis B vaccination of adolescents: Significance of non-protective antibodies

Highlights • Anti-HBs antibodies were studied in HBV vaccinated adolescents. • Low rate of non-protected subjects were found as more than ten year follow-up. • Significance of 2 IU/L predicts values >10 IU/L after booster vaccination. • A new limit at 2 IU/L is proposed.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2013-12, Vol.32 (1), p.62-68
Hauptverfasser:	Chiara, Federica, Bartolucci, Giovanni Battista, Cattai, Margherita, Piazza, Anna, Nicolli, Annamaria, Buja, Alessandra, Trevisan, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent adolescents Adult adults Allergy and Immunology Anti-HBs antibodies Antibodies, Viral - blood Antibodies, Viral - immunology Antigens Applied microbiology Biological and medical sciences Booster vaccination Child Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Hepatitis Hepatitis B Hepatitis B - immunology Hepatitis B - prevention & control Hepatitis B Vaccines - immunology Hepatitis B virus Hepatitis B virus - immunology Human viral diseases Humans immune response Immunization Immunization, Secondary Infectious diseases Male Medical sciences Microbiology patients Persistence of antibodies probability Protective antibodies ROC Curve secondary immunization students Teenagers Vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral diseases Viral hepatitis Young Adult
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Beschreibung
Zusammenfassung:	Highlights • Anti-HBs antibodies were studied in HBV vaccinated adolescents. • Low rate of non-protected subjects were found as more than ten year follow-up. • Significance of 2 IU/L predicts values >10 IU/L after booster vaccination. • A new limit at 2 IU/L is proposed.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.10.074