Benzimidazole CB2 agonists: design, synthesis and SAR
A new series of CB2-selective agonists containing a benzimidazole core is reported. Design, synthesis, SAR and pharmacokinetic data for selected compounds are described.
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2014-02, Vol.24 (4), p.1218-1221 |
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| container_end_page | 1221 |
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| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 24 |
| creator | Nanda, Kausik K Henze, Darrell A Della Penna, Kimberly Desai, Reshma Leitl, Michael Lemaire, Wei White, Rebecca B Yeh, Suzie Brouillette, Janine N Hartman, George D Bilodeau, Mark T Trotter, B Wesley |
| description | A new series of CB2-selective agonists containing a benzimidazole core is reported. Design, synthesis, SAR and pharmacokinetic data for selected compounds are described. |
| doi_str_mv | 10.1016/j.bmcl.2013.12.068 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2014-02, Vol.24 (4), p.1218-1221 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1516750999 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Benzimidazoles - chemical synthesis Benzimidazoles - chemistry Benzimidazoles - pharmacology Dose-Response Relationship, Drug Drug Design Humans Models, Molecular Molecular Structure Receptor, Cannabinoid, CB2 - agonists Structure-Activity Relationship |
| title | Benzimidazole CB2 agonists: design, synthesis and SAR |
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