Benzimidazole CB2 agonists: design, synthesis and SAR

A new series of CB2-selective agonists containing a benzimidazole core is reported. Design, synthesis, SAR and pharmacokinetic data for selected compounds are described.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2014-02, Vol.24 (4), p.1218-1221
Hauptverfasser:	Nanda, Kausik K, Henze, Darrell A, Della Penna, Kimberly, Desai, Reshma, Leitl, Michael, Lemaire, Wei, White, Rebecca B, Yeh, Suzie, Brouillette, Janine N, Hartman, George D, Bilodeau, Mark T, Trotter, B Wesley
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzimidazoles - chemical synthesis Benzimidazoles - chemistry Benzimidazoles - pharmacology Dose-Response Relationship, Drug Drug Design Humans Models, Molecular Molecular Structure Receptor, Cannabinoid, CB2 - agonists Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	A new series of CB2-selective agonists containing a benzimidazole core is reported. Design, synthesis, SAR and pharmacokinetic data for selected compounds are described.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2013.12.068