Recombinant duck enteritis virus expressing the HA gene from goose H5 subtype avian influenza virus

Highlights • Two recombinant DEVs (rDEV-ΔgIgE and rDEV-ΔUS2) were generated. • Two rDEVs expressing the AIV HA (rDEV-ΔgIgE-HA and rDEV-ΔUS2-HA) were generated. • The rDEVs and parental DEV were used to immunize four-week-old ducks. • The rDEVs immunized ducks induced specific antibodies against DEV...

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Veröffentlicht in:	Vaccine 2013-12, Vol.31 (50), p.5953-5959
Hauptverfasser:	Liu, Xiaomei, Wei, Shuangshi, Liu, Yan, Fu, Peifen, Gao, Mingchun, Mu, Xiaoyu, Liu, Hua, Xing, Mingwei, Ma, Bo, Wang, JunWei
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Anatid herpesvirus 1 Animals antibodies Antibodies, Viral - blood antigens Applied microbiology Aquatic birds Avian influenza virus Biological and medical sciences Birds Cells, Cultured Drug Carriers Duck enteritis virus (DEV) Ducks Embryos fibroblasts Fibroblasts - virology fluorescent antibody technique Fundamental and applied biological sciences. Psychology geese Gene Expression Profiling genes Genetic Vectors Genomic Instability Goose origin H5N1 avian influenza virus (AIV) Hemagglutinin (HA) Hemagglutinin Glycoproteins, Influenza Virus - genetics Hemagglutinin Glycoproteins, Influenza Virus - immunology hemagglutinins host range Immunization Influenza A virus Influenza in Birds - immunology Influenza in Birds - prevention & control Influenza Vaccines - administration & dosage Influenza Vaccines - genetics Influenza Vaccines - immunology Mardivirus - genetics Microbiology Miscellaneous pathogens Plasmids reverse transcriptase polymerase chain reaction Serial Passage vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Virology viruses Western blotting
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Beschreibung
Zusammenfassung:	Highlights • Two recombinant DEVs (rDEV-ΔgIgE and rDEV-ΔUS2) were generated. • Two rDEVs expressing the AIV HA (rDEV-ΔgIgE-HA and rDEV-ΔUS2-HA) were generated. • The rDEVs and parental DEV were used to immunize four-week-old ducks. • The rDEVs immunized ducks induced specific antibodies against DEV and AIV HA. • The rDEVs could induce partial protection against a lethal DEV virus challenge.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.10.035