Ascaridia galli infection influences the development of both humoral and cell-mediated immunity after Newcastle Disease vaccination in chickens

Highlights • A. galli infection influenced vaccine-induced immunity to Newcastle Disease (ND) in chickens. • Parasitized NDV vaccinated chickens showed lower titres of NDV specific IgG and lower frequencies NDV-specific T cells in peripheral blood than non-parasitized vaccinated controls. • Upon NDV...

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Veröffentlicht in:	Vaccine 2014-01, Vol.32 (3), p.383-392
Hauptverfasser:	Pleidrup, Janne, Dalgaard, Tina S, Norup, Liselotte R, Permin, Anders, Schou, Torben W, Skovgaard, Kerstin, Vadekær, Dorte F, Jungersen, Gregers, Sørensen, Poul, Juul-Madsen, Helle R
Format:	Artikel
Sprache:	eng
Schlagworte:	A. galli Allergy and Immunology Animals Antibodies, Viral - blood Applied microbiology Ascaridia - immunology Ascaridia galli Ascaridiasis - immunology Biological and medical sciences Chicken Chickens Fundamental and applied biological sciences. Psychology Galli Gene Expression Profiling Immune Tolerance Interleukin-13 - biosynthesis Interleukin-4 - biosynthesis Jejunum Jejunum - immunology Leukocytes, Mononuclear - immunology Microbiology Nematoda Newcastle Disease - prevention & control Newcastle disease vaccine Newcastle disease virus Newcastle disease virus - immunology Poultry Diseases - prevention & control Protective immunity Th2 cytokines Transforming Growth Factor beta - biosynthesis Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral Vaccines - administration & dosage Viral Vaccines - immunology
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Beschreibung
Zusammenfassung:	Highlights • A. galli infection influenced vaccine-induced immunity to Newcastle Disease (ND) in chickens. • Parasitized NDV vaccinated chickens showed lower titres of NDV specific IgG and lower frequencies NDV-specific T cells in peripheral blood than non-parasitized vaccinated controls. • Upon NDV challenge, viral genomes persisted in the oral cavity for a slightly longer period of time in A. galli -infected NDV vaccinees as compared to non-parasitized NDV vaccines indicating an impact of A-galli on vaccine-induced protective immunity.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.11.034