Effect of alpha-resorcylic acid–l-phenylalanine amide on collagen synthesis and matrix metalloproteinase expression in fibroblasts

α-RA-F boosted type-1 collagen synthesis and suppressed MMPs expression levels in human fibroblasts without cytotoxicity. Regulation of collagen synthesis and matrix metalloproteinases (MMPs) expression levels has been an important issue in medicinal, pharmaceutical and cosmetic industries. Herein, α-Resorcylic acid–phenylalanine amide (α-RA-F) was prepared and its biological activities were observed. We found that α-RA-F boosted collagen synthesis and reduced MMPs expression levels in human fibroblasts without cytotoxicity.