Electro-acupuncture at points of Zusanli and Quchi exerts anti-apoptotic effect through the modulation of PI3K/Akt signaling pathway

•LY294002 is used to investigate the neuroprotective mechanism of EA.•Intracerebroventricularly injected LY294002 depend on stereotaxic apparatus.•EA effectively inhibit cell apoptosis and improve cerebral IR injury.•We report EA exert the neuroprotective effect via the activation of PI3K/Akt pathwa...

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Veröffentlicht in:	Neuroscience letters 2014-01, Vol.558, p.14-19
Hauptverfasser:	Xue, Xiehua, You, Yongmei, Tao, Jing, Ye, Xiaoqian, Huang, Jia, Yang, Shanli, Lin, Zhicheng, Hong, Zhenfeng, Peng, Jun, Chen, Lidian
Format:	Artikel
Sprache:	eng
Schlagworte:	Acupuncture Points Animals Apoptosis Cerebral Infarction - pathology Cerebral Infarction - therapy Cerebral ischemia-reperfusion Chromones - pharmacology Electro-acupuncture Electroacupuncture Hypoxia-Ischemia, Brain - pathology Hypoxia-Ischemia, Brain - physiopathology Hypoxia-Ischemia, Brain - therapy Injections, Intraventricular Male Morpholines - pharmacology Neuroprutective effect Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - physiology PI3K/Akt Proto-Oncogene Proteins c-akt - physiology Rats, Sprague-Dawley Reperfusion Injury - pathology Reperfusion Injury - physiopathology Reperfusion Injury - therapy Signal Transduction
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Zusammenfassung:	•LY294002 is used to investigate the neuroprotective mechanism of EA.•Intracerebroventricularly injected LY294002 depend on stereotaxic apparatus.•EA effectively inhibit cell apoptosis and improve cerebral IR injury.•We report EA exert the neuroprotective effect via the activation of PI3K/Akt pathway. We evaluated the neuroprotective effect of electro-acupuncture (EA) on cerebral ischemia-reperfusion (IR) injury and deeply investigated the relationship between this neuroprotective effect and PI3K/Akt pathway. Rats underwent focal cerebral IR injured by suture method and received the in vivo therapeutic efficacy of EA at points of Zusanli(ST36) and Quchi(LI11) after the operation. We found that the EA treatment significantly (p
ISSN:	0304-3940 1872-7972
DOI:	10.1016/j.neulet.2013.10.029