Synthesis and antimicrobial activities of novel 1,2,4-triazolo [3,4-a] phthalazine derivatives

Synthesis and antimicrobial activities of novel 1,2,4-triazolo [3,4-a] phthalazine derivatives

A series of novel 1,2,4-triazolo [3,4-a] phthalazine derivatives were synthesized in five steps from a common precursor, phthalic anhydride. Most of synthesized phthalazine derivatives showed inhibitory activity against Staphylococcus aureus. One of phthalazine derivatives 5l showed inhibitory activ...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2014-02, Vol.24 (4), p.1236-1238
Hauptverfasser: Zhang, Qiu-Rong, Xue, Deng-Qi, He, Peng, Shao, Kun-Peng, Chen, Peng-Ju, Gu, Yi-Fei, Ren, Jing-Li, Shan, Li-Hong, Liu, Hong-Min
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Dose-Response Relationship, Drug
Microbial Sensitivity Tests
Molecular Structure
Phthalazines - chemical synthesis
Phthalazines - chemistry
Phthalazines - pharmacology
Staphylococcus aureus
Staphylococcus aureus - drug effects
Structure-Activity Relationship
Triazoles - chemical synthesis
Triazoles - chemistry
Triazoles - pharmacology
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Zusammenfassung:A series of novel 1,2,4-triazolo [3,4-a] phthalazine derivatives were synthesized in five steps from a common precursor, phthalic anhydride. Most of synthesized phthalazine derivatives showed inhibitory activity against Staphylococcus aureus. One of phthalazine derivatives 5l showed inhibitory activity against all tested bacterial and fungal strains.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2013.12.010