Chromenylchalcones with inhibitory effects on monoamine oxidase B

Structure–activity relationship (SAR) calculations were used to find monoamine oxidase-B (MAO-B) inhibitors by identifying pharmacophores exhibiting high inhibitory activities. Several such chromenylchalcones were designed and synthesized accordingly. Their inhibitory effects on MAO-B were determine...

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Veröffentlicht in:Bioorganic & medicinal chemistry 2013-12, Vol.21 (24), p.7890-7897
Hauptverfasser: Jo, Geunhyeong, Ahn, Seunghyun, Kim, Bong-Gyu, Park, Hye Ri, Kim, Young Hwa, Choo, Hyun Ah, Koh, Dongsoo, Chong, Youhoon, Ahn, Joong-Hoon, Lim, Yoongho
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Sprache:eng
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Zusammenfassung:Structure–activity relationship (SAR) calculations were used to find monoamine oxidase-B (MAO-B) inhibitors by identifying pharmacophores exhibiting high inhibitory activities. Several such chromenylchalcones were designed and synthesized accordingly. Their inhibitory effects on MAO-B were determined using an HPLC-based method and an MAO-B enzyme assay kit. (E)-3-(6-Methoxy-2H-chromen-3-yl)-1-(2-methoxyphenyl)prop-2-en-1-one exhibited a half-maximal inhibitory concentration of 320nM. Its molecular-level binding mode with the three-dimensional structure of MAO-B was elucidated using an in silico docking study. The chromenylchalcone scaffold, which is derived from natural products including isoflavonoids and chalcones, had not been previously reported as an MAO-B inhibitor.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2013.10.004