HIV-derived lentiviral particles promote T-cell independent activation and differentiation of naïve cognate conventional B2-cells in vitro

Highlights • The direct impact of lentiviral particles on cognate B cells in vitro was shown. • Activation events in B-cells after the contact with lentiviral particles. • Lentiviral particles initiated germinal center-like reactions without T-cell help. • T-independent differentiation into memory a...

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Veröffentlicht in:	Vaccine 2013-10, Vol.31 (44), p.5088-5098
Hauptverfasser:	Gardt, Oliver, Grewe, Bastian, Tippler, Bettina G, Überla, Klaus, Temchura, Vladimir V
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animal models Animals Applied microbiology B-cells B-lymphocytes B-Lymphocytes - immunology Biological and medical sciences CD4-positive T-lymphocytes CD4-Positive T-Lymphocytes - immunology CD40 Ligand - metabolism Cell Differentiation - immunology Cell Proliferation eggs Fundamental and applied biological sciences. Psychology Germinal Center - cytology Germinal Center - immunology HEK293 Cells hens HIV - immunology Human immunodeficiency virus Humans humoral immunity Immunity, Humoral immunization Immunoglobulin A - biosynthesis Immunoglobulin G - biosynthesis Immunologic Memory L-Selectin - metabolism Lentiviral VLP Lymphocyte Activation - immunology lysozyme Mice Mice, Inbred C57BL Mice, Transgenic Microbiology Miscellaneous Muramidase phenotype receptors Receptors, Antigen, B-Cell - immunology T-independent activation vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Virion - immunology Virology
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Zusammenfassung:	Highlights • The direct impact of lentiviral particles on cognate B cells in vitro was shown. • Activation events in B-cells after the contact with lentiviral particles. • Lentiviral particles initiated germinal center-like reactions without T-cell help. • T-independent differentiation into memory and IgG3 and IgA-producing cells. • Production of CD40L by cognate B-cells stimulated with lentiviral particles.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.08.055