Efficacy of the oral pentavalent rotavirus vaccine in Mali

Highlights ► We report the efficacy of the pentavalent rotavirus vaccine in Malian infants. ► Operational issues in the study design were recognized during the study. ► Case capture methods were adapted for local conditions and diarrhea reporting behaviors. ► The intention-to-treat analysis against...

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Veröffentlicht in:	Vaccine 2012-04, Vol.30, p.A71-A78
Hauptverfasser:	Sow, Samba O, Tapia, Milagritos, Haidara, Fadima C, Ciarlet, Max, Diallo, Fatoumata, Kodio, Mamoudou, Doumbia, Moussa, Dembélé, Rokiatou D, Traoré, Oumou, Onwuchekwa, Uma U, Lewis, Kristen D.C, Victor, John C, Steele, A. Duncan, Neuzil, Kathleen M, Kotloff, Karen L, Levine, Myron M
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Allergy and Immunology Antibodies, Viral - blood children confidence interval Drug-Related Side Effects and Adverse Reactions - epidemiology Efficacy trial Female field experimentation gastroenteritis Gastroenteritis - epidemiology Gastroenteritis - pathology Gastroenteritis - prevention & control health services Humans immune response Immunoglobulin A - blood immunoglobulins Infant infants Male Mali Mali - epidemiology monitoring Placebos - administration & dosage Rotavirus Rotavirus Infections - epidemiology Rotavirus Infections - pathology Rotavirus Infections - prevention & control Rotavirus vaccine Rotavirus Vaccines - administration & dosage Rotavirus Vaccines - adverse effects Rotavirus Vaccines - immunology Severe gastroenteritis Severity of Illness Index vaccination Vaccination - adverse effects Vaccination - methods vaccines Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - adverse effects Vaccines, Attenuated - immunology
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Beschreibung
Zusammenfassung:	Highlights ► We report the efficacy of the pentavalent rotavirus vaccine in Malian infants. ► Operational issues in the study design were recognized during the study. ► Case capture methods were adapted for local conditions and diarrhea reporting behaviors. ► The intention-to-treat analysis against severe rotavirus gastroenteritis was 42.9%.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2011.11.094