Complement Profile in Neonates of Different Gestational Ages

Blood levels of regulators of the complement system in preterm babies were reported in few studies only. The aim of this study was to set up a complement profile in premature and term babies focusing on the development of blood levels of MBL, key regulatory proteins and on classical pathway activity...

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Veröffentlicht in:	Scandinavian journal of immunology 2014-04, Vol.79 (4), p.276-281
Hauptverfasser:	Grumach, A. S., Ceccon, M. E., Rutz, R., Fertig, A., Kirschfink, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Complement Activation Complement C1 Inhibitor Protein - genetics Complement C1 Inhibitor Protein - metabolism Complement C3a - genetics Complement C3a - metabolism Complement Factor H - genetics Complement Factor H - metabolism Complement Hemolytic Activity Assay Female Fibrinogen - genetics Fibrinogen - metabolism Gene Expression Regulation, Developmental Gestational Age Humans Infant, Newborn Mannose-Binding Lectin - genetics Mannose-Binding Lectin - metabolism Pregnancy Premature Birth - immunology Properdin - genetics Properdin - metabolism
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Beschreibung
Zusammenfassung:	Blood levels of regulators of the complement system in preterm babies were reported in few studies only. The aim of this study was to set up a complement profile in premature and term babies focusing on the development of blood levels of MBL, key regulatory proteins and on classical pathway activity, which may allow an estimation of potential susceptibility to infection. Complement activity (CH50), levels of mannan‐binding lectin (MBL), complement regulators (factors H and I, C1 inhibitor, properdin) and C3a as marker of complement activation were assessed in three groups of healthy newborns: (1) prematures (≤34 weeks); (2) late prematures (>34–
ISSN:	0300-9475 1365-3083
DOI:	10.1111/sji.12154