Gauche + side-chain orientation as a key factor in the search for an immunogenic peptide mixture leading to a complete fully protective vaccine

Highlights • χ1 angle in position 3 determines full protective immunity. • Positions p3 and p7 displayed specific side-chain gauche + orientation. • Fully protective anti-malarial vaccine mixtures. • Principles that allow new possibilities for advance of new methods for vaccines.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2014-04, Vol.32 (18), p.2117-2126
Hauptverfasser:	Bermúdez, Adriana, Calderon, Dayana, Moreno-Vranich, Armando, Almonacid, Hannia, Patarroyo, Manuel A, Poloche, Andrés, Patarroyo, Manuel E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Allergy and Immunology Amino Acid Sequence Amino acids Animals Antibodies, Protozoan - blood Antibody Formation Antimalarial vaccine Aotus trivirgatus Applied microbiology Binding Sites Biological and medical sciences Fundamental and applied biological sciences. Psychology Gauche HLA-DR beta-Chains - immunology Immune response Malaria Malaria Vaccines - chemistry Malaria, Falciparum - prevention & control Microbiology Molecular Sequence Data Oligopeptides - chemical synthesis Oligopeptides - immunology Parasites Peptide mixtures Peptides Protective immunity Protein Conformation Proteins Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vector-borne diseases χ1 angle
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Beschreibung
Zusammenfassung:	Highlights • χ1 angle in position 3 determines full protective immunity. • Positions p3 and p7 displayed specific side-chain gauche + orientation. • Fully protective anti-malarial vaccine mixtures. • Principles that allow new possibilities for advance of new methods for vaccines.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2014.02.003