Gene expression changes in rat brain after short and long exposures to particulate matter in Los Angeles basin air: Comparison with human brain tumors

Air pollution negatively impacts pulmonary, cardiovascular, and central nervous systems. Although its influence on brain cancer is unclear, toxic pollutants can cause blood–brain barrier disruption, enabling them to reach the brain and cause alterations leading to tumor development. By gene microarr...

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Veröffentlicht in:	Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2013-11, Vol.65 (7-8), p.1063-1071
Hauptverfasser:	Ljubimova, Julia Y., Kleinman, Michael T., Karabalin, Natalya M., Inoue, Satoshi, Konda, Bindu, Gangalum, Pallavi, Markman, Janet L., Ljubimov, Alexander V., Black, Keith L.
Format:	Artikel
Sprache:	eng
Schlagworte:	air air pollution Air Pollution - adverse effects Air pollution particles Animals Arc/Arg3.1 blood-brain barrier brain Brain Neoplasms - genetics Brain tumor Chronic exposure Cytoskeletal Proteins - biosynthesis Cytoskeletal Proteins - genetics gene expression gene expression regulation Gene Expression Regulation - drug effects Gene microarray genes Humans Immunohistochemistry inhalation exposure Los Angeles Male microarray technology neoplasms Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Oligonucleotide Array Sequence Analysis Particulate Matter - adverse effects particulates pollutants protein products Rac1 rac1 GTP-Binding Protein - biosynthesis rac1 GTP-Binding Protein - genetics Rats Rats, Inbred F344 Real-Time Polymerase Chain Reaction reverse transcriptase polymerase chain reaction toxicity Transcriptome
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Zusammenfassung:	Air pollution negatively impacts pulmonary, cardiovascular, and central nervous systems. Although its influence on brain cancer is unclear, toxic pollutants can cause blood–brain barrier disruption, enabling them to reach the brain and cause alterations leading to tumor development. By gene microarray analysis validated by quantitative RT-PCR and immunostaining we examined whether rat (n=104) inhalation exposure to air pollution particulate matter (PM) resulted in brain molecular changes similar to those associated with human brain tumors. Global brain gene expression was analyzed after exposure to PM (coarse, 2.5–10μm; fine,
ISSN:	0940-2993 1618-1433
DOI:	10.1016/j.etp.2013.04.002