Impact of Major Bleeding on Long-Term Mortality in Anemic Versus Nonanemic Patients Undergoing Percutaneous Coronary Intervention Using Bivalirudin

Bleeding complications after percutaneous coronary intervention (PCI) have been associated with higher short and long-term mortality. Bivalirudin has been shown to reduce bleeding complications in patients who underwent PCI; however, the impact of anemia on bleeding complications and long-term morta...

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Veröffentlicht in:	The American journal of cardiology 2014-05, Vol.113 (9), p.1481-1486
Hauptverfasser:	Ali, Ziad A., MD, DPhil, Poludasu, Shyam, MD, Qureshi, Yasir H., MD, Krishnan, Prakash, MD, Ali, Ayyaz A., MD, Tatonetti, Nicholas, PhD, Downey, Peter, MD, Zalewski, Adrian, BSc, Nazif, Tamim, MD, George, Isaac, MD, Mandava, Anupa, MD, Baber, Usman, MD, Dangas, George, MD, Mehran, Roxana, MD, Kini, Annapoorna S., MD, Sharma, Samin K., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute coronary syndromes Age Aged Anemia Anemia, Hypochromic - complications Antithrombins - therapeutic use Body mass index Cardiovascular Diabetes Female Heart attacks Hemorrhage - complications Hirudins Humans Kidney diseases Male Mortality Normal distribution Peptide Fragments - therapeutic use Percutaneous Coronary Intervention - mortality Postoperative Complications - mortality Postoperative Complications - prevention & control Recombinant Proteins - therapeutic use Stents Studies Variables
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Zusammenfassung:	Bleeding complications after percutaneous coronary intervention (PCI) have been associated with higher short and long-term mortality. Bivalirudin has been shown to reduce bleeding complications in patients who underwent PCI; however, the impact of anemia on bleeding complications and long-term mortality has not been studied. A total of 11,991 patients who underwent PCI over a period of 8 years with bivalirudin as the primary antithrombotic agent were included. Anemia was defined according to the World Health Organization definition. Bleeding complications were prospectively collected. Survival analysis was performed using multivariable Cox proportional hazards models. Of the 11,991 patients, 4,815 patients (40%) had baseline anemia. Major bleeding occurred in 3.3% of patients with anemia compared with 0.7% of patients without anemia (p
ISSN:	0002-9149 1879-1913
DOI:	10.1016/j.amjcard.2014.01.427