Necroptosis inhibitor necrostatin-1 promotes cell protection and physiological function in traumatic spinal cord injury

Highlights • Nec-1 reduces ischemia lesions, inhibits inflammation and ROS after SCI. • Nec-1 inhibits necroptosis by inhibiting RIP1/3–MLKL recruitment after SCI. • Nec-1 inhibits apoptosis by down-regulation of Caspase 3 and Bax/Bcl-2 ratio. • Nec-1 protects neurons, promotes functional recovery a...

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Veröffentlicht in:	Neuroscience 2014-04, Vol.266, p.91-101
Hauptverfasser:	Wang, Y, Wang, H, Tao, Y, Zhang, S, Wang, J, Feng, X
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis Apoptosis - drug effects Blotting, Western cell protection Disease Models, Animal Imidazoles - pharmacology Immunohistochemistry In Situ Nick-End Labeling Indoles - pharmacology Male necroptosis Necrosis - prevention & control necrostatin-1 Neurology Neuroprotective Agents - pharmacology physiological function Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Recovery of Function - drug effects Spinal Cord Injuries - drug therapy Spinal Cord Injuries - pathology spinal cord injury
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Beschreibung
Zusammenfassung:	Highlights • Nec-1 reduces ischemia lesions, inhibits inflammation and ROS after SCI. • Nec-1 inhibits necroptosis by inhibiting RIP1/3–MLKL recruitment after SCI. • Nec-1 inhibits apoptosis by down-regulation of Caspase 3 and Bax/Bcl-2 ratio. • Nec-1 protects neurons, promotes functional recovery and ethological improvement. • Nec-1 might be a potential drug with high protection effects and low toxicity for SCI.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.02.007