Baicalein ameliorated the upregulation of striatal glutamatergic transmission in the mice model of Parkinson's disease

Highlights • Baicalein attenuated the upregulation of striatal glutamate transmission. • Baicalein attenuated the striatal cytokine synthesis in the PD mice. • Baicalein improved the motor balance in the PD mice.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain research bulletin 2014-04, Vol.103, p.54-59
Hauptverfasser:	Xue, Xinhong, Liu, Hong, Qi, Lifeng, Li, Xueli, Guo, Cunju, Gong, Dianrong, Qu, Huaiqian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Baicalein Corpus Striatum - drug effects Cytokines - metabolism Disease Models, Animal Flavanones - pharmacology Glutamatergic transmission Glutamic Acid - metabolism Male Mice Mice, Inbred C57BL Motor Activity - drug effects MPTP Poisoning - physiopathology Neurology Parkinson's disease Receptors, AMPA - metabolism Rotarod task Striatum Synaptic Transmission - drug effects Up-Regulation
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Beschreibung
Zusammenfassung:	Highlights • Baicalein attenuated the upregulation of striatal glutamate transmission. • Baicalein attenuated the striatal cytokine synthesis in the PD mice. • Baicalein improved the motor balance in the PD mice.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2014.02.004