The effects of buspirone, a selective anxiolytic, on stress ulcer formation in rats

The effects of buspirone, a selective anxiolytic, on stress ulcer formation in rats

The effects of buspirone hydrochloride were investigated in the formation of cold-immobilization gastric stress ulcers. Low doses significantly attenuated, while higher doses greatly potentiated gastric stress pathology. The dopamine antagonist haloperidol, and the agonist apomorphine respectively,...

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Veröffentlicht in:Pharmacology, biochemistry and behavior biochemistry and behavior, 1988-10, Vol.31 (2), p.317-319
Hauptverfasser: Sullivan, Ronald M., Henke, Peter G., Ray, Arunabha
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Anxiety
Apomorphine - pharmacology
Biological and medical sciences
Buspirone
Buspirone - pharmacology
Dopamine
Dopamine - physiology
Dose-Response Relationship, Drug
Drug Interactions
Haloperidol - pharmacology
Injections, Intraperitoneal
Male
Medical sciences
Neuropharmacology
Nonbenzodiazepine
Pharmacology. Drug treatments
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Rats, Inbred Strains
Stomach - pathology
Stomach Ulcer - pathology
Stress ulcer
Stress, Physiological
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Zusammenfassung:The effects of buspirone hydrochloride were investigated in the formation of cold-immobilization gastric stress ulcers. Low doses significantly attenuated, while higher doses greatly potentiated gastric stress pathology. The dopamine antagonist haloperidol, and the agonist apomorphine respectively, reversed the buspirone effects. The role of dopamine in the expression of buspirone's effects is discussed, although other transmitter systems may mediate some of the actions of buspirone.
ISSN:0091-3057
1873-5177
DOI:10.1016/0091-3057(88)90352-8