Addition of plerixafor for CD34+ cell mobilization in six healthy stem cell donors ensured satisfactory grafts for transplantation

Background In allogeneic hematopoietic stem cell (HSC) transplantation, collection of a sufficient number of HSCs at a fixed time point is crucial. For HSC mobilization into the peripheral blood, the standard regimen, that is, granulocyte–colony‐stimulating factor (G‐CSF), may be inadequate. Use of...

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Veröffentlicht in:Transfusion (Philadelphia, Pa.) Pa.), 2014-04, Vol.54 (4), p.1055-1058
Hauptverfasser: Hauge, Anne Werner, Haastrup, Eva Kannik, Sengeløv, Henrik, Minulescu, Lia, Dickmeiss, Ebbe, Fischer-Nielsen, Anne
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Sprache:eng
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Zusammenfassung:Background In allogeneic hematopoietic stem cell (HSC) transplantation, collection of a sufficient number of HSCs at a fixed time point is crucial. For HSC mobilization into the peripheral blood, the standard regimen, that is, granulocyte–colony‐stimulating factor (G‐CSF), may be inadequate. Use of plerixafor as adjuvant to G‐CSF is so far off‐label in healthy donors. Study Design and Methods We present six cases in which the “just‐in‐time” addition of plerixafor ensured proper CD34+ collection from healthy donors with insufficient G‐CSF mobilization. In four of these cases a high number of CD34+ cells was needed due to subsequent CD34+ selection or haploidentical transplantation. Results From all six donors a sufficient number of CD34+ cells was obtained by using plerixafor as an adjuvant to G‐CSF. This treatment regimen resulted in only mild side effects for the donor. Conclusion We have presented six cases with different causes leading to insufficient G‐CSF mobilization in allogeneic donors and in which the administration of plerixafor just‐in‐time ensured a proper graft for transplantation.
ISSN:0041-1132
1537-2995
DOI:10.1111/trf.12383