Adhesion molecules as predictors of nasal polyposis recurrence

Nasal polyposis is a chronic inflammation of nasal and paranasal sinuses in the pathogenesis of which adhesion molecules may have a significant role. This study investigates the possible role of certain adhesion molecules, mucins, and oncogenes in nasal polyposis recurrence. A sample study of 21 ind...

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Veröffentlicht in:American journal of rhinology & allergy 2014-01, Vol.28 (1), p.20-22
Hauptverfasser: Batzakakis, Dimitrios, Stathas, Theodoros, Mastronikolis, Nikos, Kourousis, Christos, Aletras, Alexandros, Naxakis, Stephanos
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Sprache:eng
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Zusammenfassung:Nasal polyposis is a chronic inflammation of nasal and paranasal sinuses in the pathogenesis of which adhesion molecules may have a significant role. This study investigates the possible role of certain adhesion molecules, mucins, and oncogenes in nasal polyposis recurrence. A sample study of 21 individuals (17 men and 4 women) aged 47.44 ± 15.10 years with nasal polyposis who had undergone nasal surgery twice was used. Twenty-one individuals aged 46.9 ± 12.8 years suffering from nasal polyposis who had undergone surgery only once in the same period were used as a control sample. Statistically significant differences between the two groups were observed regarding epithelial membrane antigen (EMA/mucin 1) of stromal cells (p < 0.001) and CD86 stromal expression (p = 0.009). No patient of the control group exhibited high (++) CD86 stromal expression, whereas six patients of the resurgery group did so. When EMA and CD86 were included in a logistic regression model, stromal EMA was found to be positively related to recurrence. Adhesion molecules may relate to nasal polyp prognosis and recurrence rates.
ISSN:1945-8924
1945-8932
DOI:10.2500/ajra.2014.28.3962