Tissue accumulation and toxicity of isothiazolinone in Ctenopharyngodon idellus (grass carp): Association with P-glycoprotein expression and location within tissues
Highlights • The LC50 values of isothiazolinone decreased as the temperature increased. • P-gp mRNA expression in isothiazolinone-treated groups was significantly more. • Temperature affected accumulation and toxicity of isothiazolinone.
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| Veröffentlicht in: | Environmental toxicology and pharmacology 2014-03, Vol.37 (2), p.529-535 |
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| container_end_page | 535 |
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| container_issue | 2 |
| container_start_page | 529 |
| container_title | Environmental toxicology and pharmacology |
| container_volume | 37 |
| creator | Hu, Kun Li, Hao-Ran Ou, Ren-Jian Li, Chun-Zeng Yang, Xian-Le |
| description | Highlights • The LC50 values of isothiazolinone decreased as the temperature increased. • P-gp mRNA expression in isothiazolinone-treated groups was significantly more. • Temperature affected accumulation and toxicity of isothiazolinone. |
| doi_str_mv | 10.1016/j.etap.2013.12.017 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1382-6689 |
| ispartof | Environmental toxicology and pharmacology, 2014-03, Vol.37 (2), p.529-535 |
| issn | 1382-6689 1872-7077 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Carps - metabolism Ctenopharyngodon idellus Emergency Expression Fungicides, Industrial - pharmacokinetics Fungicides, Industrial - toxicity Isothiazolinone Kidney - drug effects Kidney - metabolism Liver - drug effects Liver - metabolism Location P-glycoprotein RNA, Messenger - metabolism Thiazoles - toxicity Toxicity Water Pollutants, Chemical - pharmacokinetics Water Pollutants, Chemical - toxicity |
| title | Tissue accumulation and toxicity of isothiazolinone in Ctenopharyngodon idellus (grass carp): Association with P-glycoprotein expression and location within tissues |
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