Tissue accumulation and toxicity of isothiazolinone in Ctenopharyngodon idellus (grass carp): Association with P-glycoprotein expression and location within tissues

Highlights • The LC50 values of isothiazolinone decreased as the temperature increased. • P-gp mRNA expression in isothiazolinone-treated groups was significantly more. • Temperature affected accumulation and toxicity of isothiazolinone.

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Bibliographische Detailangaben
Veröffentlicht in:	Environmental toxicology and pharmacology 2014-03, Vol.37 (2), p.529-535
Hauptverfasser:	Hu, Kun, Li, Hao-Ran, Ou, Ren-Jian, Li, Chun-Zeng, Yang, Xian-Le
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Carps - metabolism Ctenopharyngodon idellus Emergency Expression Fungicides, Industrial - pharmacokinetics Fungicides, Industrial - toxicity Isothiazolinone Kidney - drug effects Kidney - metabolism Liver - drug effects Liver - metabolism Location P-glycoprotein RNA, Messenger - metabolism Thiazoles - toxicity Toxicity Water Pollutants, Chemical - pharmacokinetics Water Pollutants, Chemical - toxicity
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Beschreibung
Zusammenfassung:	Highlights • The LC50 values of isothiazolinone decreased as the temperature increased. • P-gp mRNA expression in isothiazolinone-treated groups was significantly more. • Temperature affected accumulation and toxicity of isothiazolinone.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2013.12.017