Studies on the effect of sodium arsenate on the enzymes of carbohydrate metabolism, brush border membrane, and oxidative stress in the rat kidney

Highlights • ARS administration produces nephrotoxicity. • ARS causes ultra structural alterations in the kidney. • The renal proximal tubule, particularly its BBM seems to be the major ARS target. • ARS appeared to shift energy dependence from aerobic to anaerobic glycolysis by causing damage to mi...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2014-03, Vol.37 (2), p.592-599
Hauptverfasser:	Shahid, Faaiza, Rizwan, Sana, Khan, Md. Wasim, Khan, Sara Anees, Naqshbandi, Ashreeb, Yusufi, Ahad Noor Khan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arsenates - toxicity Brush border membrane enzymes Carbohydrate metabolism Carbohydrate Metabolism - drug effects Emergency Kidney - drug effects Kidney - metabolism Kidney - pathology Lysosomes - drug effects Lysosomes - metabolism Male Microvilli - drug effects Microvilli - metabolism Oxidative stress Oxidative Stress - drug effects Oxidoreductases - metabolism Rat kidney Rats, Wistar Sodium arsenate Transferases - metabolism
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Zusammenfassung:	Highlights • ARS administration produces nephrotoxicity. • ARS causes ultra structural alterations in the kidney. • The renal proximal tubule, particularly its BBM seems to be the major ARS target. • ARS appeared to shift energy dependence from aerobic to anaerobic glycolysis by causing damage to mitochondria. • ARS caused nephrotoxic and other deleterious effects by increasing ROS generation.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2014.01.012