Effects of n -butylparaben on steroidogenesis and spermatogenesis through changed E2 levels in male rat offspring

Highlights • We investigated the adverse effects exposure to n -BP in utero and during lactation period. • The results showed male reproductive toxicity by n -BP exposure with NOAEL 160 mg/kg/day. • Serum testosterone and estradiol (E2 ) were significantly changed in male offspring. • First study th...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2014-03, Vol.37 (2), p.705-717
Hauptverfasser:	Zhang, Linyuan, Dong, Li, Ding, Sijin, Qiao, Peihuan, Wang, Chong, Zhang, Ming, Zhang, Lixia, Du, Qingcheng, Li, Yimin, Tang, Ning, Chang, Bing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Emergency Endocrine disrupting chemicals Estradiol - blood Female Follicle Stimulating Hormone - blood Luteinizing Hormone - blood Male Maternal-Fetal Exchange Oestrogene Organ Size - drug effects Parabens Parabens - toxicity Pregnancy Prenatal Exposure Delayed Effects Rats, Wistar Reproduction Sperm Count Spermatogenesis - drug effects Testis - drug effects Testis - pathology Testosterone Testosterone - blood
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Beschreibung
Zusammenfassung:	Highlights • We investigated the adverse effects exposure to n -BP in utero and during lactation period. • The results showed male reproductive toxicity by n -BP exposure with NOAEL 160 mg/kg/day. • Serum testosterone and estradiol (E2 ) were significantly changed in male offspring. • First study that reports increased E2 levels in male rats following n -BP exposure. • E2 levels may be considered as biomarkers for some endocrine disrupting chemicals.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2014.01.016