Andrographolide sodium bisulfate-induced apoptosis and autophagy in human proximal tubular endothelial cells is a ROS-mediated pathway

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Veröffentlicht in:	Environmental toxicology and pharmacology 2014-03, Vol.37 (2), p.718-728
Hauptverfasser:	Lu, Hong, Zhang, Xin-Yue, Wang, Yi-Qi, Zheng, Xiao-Liang, Yin-Zhao, Xing, Wen-Min, Zhang, Qin
Format:	Artikel
Sprache:	eng
Schlagworte:	Andrographolide sodium bisulfate Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Autophagy Autophagy - drug effects bcl-2-Associated X Protein - metabolism Beclin-1 Caspase 3 - metabolism Caspase 9 - metabolism Cell Line Cytochromes c - metabolism Diterpenes - toxicity Emergency Endothelial Cells - drug effects Endothelial Cells - metabolism Glutathione - metabolism Human proximal tubular endothelial cell Humans JNK Mitogen-Activated Protein Kinases - metabolism Kidney Tubules, Proximal - cytology Membrane Potential, Mitochondrial - drug effects Membrane Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Sulfates - toxicity Superoxide Dismutase - metabolism
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