Serum dipeptidyl peptidase-IV: A better screening test for early detection of mucopolysaccharidosis?

We aimed to investigate the diagnostic utility of serum DPP-IV enzyme activity, urinary GAG/Cre ratio, chitotriosidase activity, total adenosine deaminase (ADA) and ADA-1 isoenzyme activity in the diagnosis of MPS. 31 MPS patients which were previously diagnosed by clinical and enzymatic analysis an...

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Veröffentlicht in:	Clinica chimica acta 2014-04, Vol.431, p.250-254
Hauptverfasser:	Kurt, Ismail, Sertoglu, Erdim, Okur, Ilyas, Tapan, Serkan, Uyanık, Metin, Kayadıbı, Huseyin, Ezgu, Fatih Suheyl, Aydın, Halil Ibrahim, Hasanoglu, Alev
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Deaminase - blood Adolescent Child Creatinine - urine Dipeptidyl Peptidase 4 - blood Early Diagnosis Female Glycosaminoglycans - urine Hexosaminidases - blood Humans Isoenzymes - blood Male Mucopolysaccharidoses Mucopolysaccharidoses - blood Mucopolysaccharidoses - diagnosis Mucopolysaccharidoses - enzymology Reproducibility of Results Serum DPP-IV enzyme activity Urinary GAG/Creatinine ratio
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Zusammenfassung:	We aimed to investigate the diagnostic utility of serum DPP-IV enzyme activity, urinary GAG/Cre ratio, chitotriosidase activity, total adenosine deaminase (ADA) and ADA-1 isoenzyme activity in the diagnosis of MPS. 31 MPS patients which were previously diagnosed by clinical and enzymatic analysis and 31 healthy controls matched with age and gender were included in this study. Serum DPP-IV enzyme activity, urinary GAG/Cre ratio, total ADA and ADA-1 isoenzyme activity were significantly higher in patients than in controls (p
ISSN:	0009-8981 1873-3492
DOI:	10.1016/j.cca.2014.02.012