Lipotoxicity, β Cell Dysfunction, and Gestational Diabetes

Lipotoxicity, β Cell Dysfunction, and Gestational Diabetes

Gestational diabetes (GDM) is caused by failure of islet β cells to meet the increased insulin requirements of pregnancy. Recently, Prentice et al. (2014) discovered a 7-fold elevation of the furan fatty acid metabolite 3-carboxy-4-methyl-5-propyl-2-furanopropanoic acid (CMPF) in plasma of women wit...

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Veröffentlicht in:Cell metabolism 2014-04, Vol.19 (4), p.553-554
1. Verfasser: Nolan, Christopher J.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Furans - blood
Humans
Insulin-Secreting Cells - pathology
Mitochondria - pathology
Models, Biological
Organic Anion Transporters, Sodium-Independent - metabolism
Propionates - blood
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Zusammenfassung:Gestational diabetes (GDM) is caused by failure of islet β cells to meet the increased insulin requirements of pregnancy. Recently, Prentice et al. (2014) discovered a 7-fold elevation of the furan fatty acid metabolite 3-carboxy-4-methyl-5-propyl-2-furanopropanoic acid (CMPF) in plasma of women with GDM and showed that CMPF directly induces β cell dysfunction.
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2014.03.020