Psychophysiological correlates of coping and quality of life in patients with ALS

Highlights • N400 event-related potentials can be reliably elicited in patients with amyotrophic lateral sclerosis and quality of life modulates the N400 amplitude in response to incongruent disease-related words. • Healthy subjects do not show this effect. • N400 modulation might serve as a psychop...

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Veröffentlicht in:	Clinical neurophysiology 2014-05, Vol.125 (5), p.955-961
Hauptverfasser:	Real, R.G.L, Herbert, C, Kotchoubey, B, Wessig, C, Volkmann, J, Kübler, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Psychological ALS Amyotrophic Lateral Sclerosis - complications Amyotrophic Lateral Sclerosis - physiopathology Amyotrophic Lateral Sclerosis - psychology Chronic Disease Coping Depression - complications Depression - diagnosis Depression - physiopathology Depression - psychology EEG Electroencephalography Evoked Potentials - physiology Female Humans Male Middle Aged N400 Neurology Population Surveillance Quality of Life Reaction Time - physiology Reading Semantics Surveys and Questionnaires
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Beschreibung
Zusammenfassung:	Highlights • N400 event-related potentials can be reliably elicited in patients with amyotrophic lateral sclerosis and quality of life modulates the N400 amplitude in response to incongruent disease-related words. • Healthy subjects do not show this effect. • N400 modulation might serve as a psychophysiological correlate of quality of life.
ISSN:	1388-2457 1872-8952
DOI:	10.1016/j.clinph.2013.09.040