Dopamine-induced hypophagia is mediated by D1 and 5HT-2c receptors in chicken
The present study was designed to examine the effects of intracerebroventricular (ICV) injection of Dopamine (10, 20 and 40 nmol), L-DOPA (dopamine precursor; 62.5, 125 and 250 nmol), 6-OHDA (dopamine inhibitor; 75, 150 and 300 nmol), SCH 23390 (D₁ antagonist; 2.5, 5 and 10 nmol), AMI-193 (D₂ antago...
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| Veröffentlicht in: | Veterinary research communications 2014-03, Vol.38 (1), p.11-19 |
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| creator | Zendehdel, Morteza Hasani, Keyvan Babapour, Vahab Mortezaei, Sepideh Seyedali Khoshbakht, Yalda Hassanpour, Shahin |
| description | The present study was designed to examine the effects of intracerebroventricular (ICV) injection of Dopamine (10, 20 and 40 nmol), L-DOPA (dopamine precursor; 62.5, 125 and 250 nmol), 6-OHDA (dopamine inhibitor; 75, 150 and 300 nmol), SCH 23390 (D₁ antagonist; 2.5, 5 and 10 nmol), AMI-193 (D₂ antagonist; 2.5, 5 and 10 nmol), NGB2904 (D₃ antagonist; 3.2, 6.4 and 12.8 nmol), L-741 T742 (D₄ antagonist; 1.5, 3 and 6 nmol) on food intake in FD₃ chickens. At following, birds were ICV injected using 8-OH-DPAT (5-HT₁A agonist; 15.25 nmol) and SB242084 (5-HT₂C antagonist; 1.5 μg) prior dopamine (40 nmol) injection. Cumulative food intake was determined until 3 h post-injection. According to the results, dopamine significantly decreased food intake in chickens (p |
| doi_str_mv | 10.1007/s11259-013-9581-y |
| format | Article |
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At following, birds were ICV injected using 8-OH-DPAT (5-HT₁A agonist; 15.25 nmol) and SB242084 (5-HT₂C antagonist; 1.5 μg) prior dopamine (40 nmol) injection. Cumulative food intake was determined until 3 h post-injection. According to the results, dopamine significantly decreased food intake in chickens (p < 0.05). The inhibitory effect of dopamine on food intake was decreased by SCH 23390 pretreatment (P < 0.05), but AMI-193, NGB2904 and L-741, 742 had no effect on food intake induced by dopamine. In addition, hypophagic effect of dopamine was attenuated by SB242084 (P < 0.05), but 8-OH-DPAT had no effect. These results suggest that dopamine decrease food intake via D₁ receptor and there is an interaction between dopaminergic and serotonergic systems via 5-HT₂C receptor in chickens.</description><identifier>ISSN: 0165-7380</identifier><identifier>EISSN: 1573-7446</identifier><identifier>DOI: 10.1007/s11259-013-9581-y</identifier><identifier>PMID: 24122738</identifier><language>eng</language><publisher>Dordrecht: Springer-Verlag</publisher><subject>Animals ; antagonists ; Biomedical and Life Sciences ; Chickens ; dopamine ; Dopamine - pharmacology ; Eating - drug effects ; food intake ; L-dopa ; Life Sciences ; Male ; Neurotransmitter Agents - pharmacology ; Original Article ; Protein Binding - drug effects ; Random Allocation ; receptors ; Receptors, Dopamine D1 - metabolism ; undereating ; Veterinary Medicine/Veterinary Science ; Zoology</subject><ispartof>Veterinary research communications, 2014-03, Vol.38 (1), p.11-19</ispartof><rights>Springer Science+Business Media Dordrecht 2013</rights><rights>Springer Science+Business Media Dordrecht 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-81fd5b4ed8401a7275ca14d42620b8df69252d09b632b77e6162e25fcd700d103</citedby><cites>FETCH-LOGICAL-c462t-81fd5b4ed8401a7275ca14d42620b8df69252d09b632b77e6162e25fcd700d103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11259-013-9581-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11259-013-9581-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24122738$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zendehdel, Morteza</creatorcontrib><creatorcontrib>Hasani, Keyvan</creatorcontrib><creatorcontrib>Babapour, Vahab</creatorcontrib><creatorcontrib>Mortezaei, Sepideh Seyedali</creatorcontrib><creatorcontrib>Khoshbakht, Yalda</creatorcontrib><creatorcontrib>Hassanpour, Shahin</creatorcontrib><title>Dopamine-induced hypophagia is mediated by D1 and 5HT-2c receptors in chicken</title><title>Veterinary research communications</title><addtitle>Vet Res Commun</addtitle><addtitle>Vet Res Commun</addtitle><description>The present study was designed to examine the effects of intracerebroventricular (ICV) injection of Dopamine (10, 20 and 40 nmol), L-DOPA (dopamine precursor; 62.5, 125 and 250 nmol), 6-OHDA (dopamine inhibitor; 75, 150 and 300 nmol), SCH 23390 (D₁ antagonist; 2.5, 5 and 10 nmol), AMI-193 (D₂ antagonist; 2.5, 5 and 10 nmol), NGB2904 (D₃ antagonist; 3.2, 6.4 and 12.8 nmol), L-741 T742 (D₄ antagonist; 1.5, 3 and 6 nmol) on food intake in FD₃ chickens. At following, birds were ICV injected using 8-OH-DPAT (5-HT₁A agonist; 15.25 nmol) and SB242084 (5-HT₂C antagonist; 1.5 μg) prior dopamine (40 nmol) injection. Cumulative food intake was determined until 3 h post-injection. According to the results, dopamine significantly decreased food intake in chickens (p < 0.05). The inhibitory effect of dopamine on food intake was decreased by SCH 23390 pretreatment (P < 0.05), but AMI-193, NGB2904 and L-741, 742 had no effect on food intake induced by dopamine. In addition, hypophagic effect of dopamine was attenuated by SB242084 (P < 0.05), but 8-OH-DPAT had no effect. These results suggest that dopamine decrease food intake via D₁ receptor and there is an interaction between dopaminergic and serotonergic systems via 5-HT₂C receptor in chickens.</description><subject>Animals</subject><subject>antagonists</subject><subject>Biomedical and Life Sciences</subject><subject>Chickens</subject><subject>dopamine</subject><subject>Dopamine - pharmacology</subject><subject>Eating - drug effects</subject><subject>food intake</subject><subject>L-dopa</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Neurotransmitter Agents - pharmacology</subject><subject>Original Article</subject><subject>Protein Binding - drug effects</subject><subject>Random Allocation</subject><subject>receptors</subject><subject>Receptors, Dopamine D1 - metabolism</subject><subject>undereating</subject><subject>Veterinary Medicine/Veterinary Science</subject><subject>Zoology</subject><issn>0165-7380</issn><issn>1573-7446</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kcFu1DAQhi0EokvhAbhAJC5cTGcmdhwfUQu0UlEPtGfLsZ1dl90k2JtD3h5XKQhx6MmS5_t_jz4z9hbhEwKos4xIUnPAmmvZIl-esQ1KVXMlRPOcbQAbyVXdwgl7lfM9AOgW6pfshAQSlcGGfb8YJ3uIQ-Bx8LMLvtot0zjt7DbaKubqEHy0x3LdLdUFVnbwlby85eSqFFyYjmPKVRwqt4vuZxhesxe93efw5vE8ZXdfv9yeX_Lrm29X55-vuRMNHXmLvZedCL4VgFaRks6i8IIagq71faNJkgfdNTV1SoUGGwoke-cVgEeoT9nHtXdK46855KM5xOzCfm-HMM7ZoEQhSOtGFfTDf-j9OKehbGdQ6FajkJIKhSvl0phzCr2ZUjzYtBgE8-DarK5NcW0eXJulZN49Ns9d0fQ38UduAWgFchkN25D-efqJ1vdrqLejsdsUs7n7QYCi_B6CJlH_Bi6skCk</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Zendehdel, Morteza</creator><creator>Hasani, Keyvan</creator><creator>Babapour, Vahab</creator><creator>Mortezaei, Sepideh Seyedali</creator><creator>Khoshbakht, Yalda</creator><creator>Hassanpour, Shahin</creator><general>Springer-Verlag</general><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20140301</creationdate><title>Dopamine-induced hypophagia is mediated by D1 and 5HT-2c receptors in chicken</title><author>Zendehdel, Morteza ; Hasani, Keyvan ; Babapour, Vahab ; Mortezaei, Sepideh Seyedali ; Khoshbakht, Yalda ; Hassanpour, Shahin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-81fd5b4ed8401a7275ca14d42620b8df69252d09b632b77e6162e25fcd700d103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>antagonists</topic><topic>Biomedical and Life Sciences</topic><topic>Chickens</topic><topic>dopamine</topic><topic>Dopamine - pharmacology</topic><topic>Eating - drug effects</topic><topic>food intake</topic><topic>L-dopa</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Neurotransmitter Agents - pharmacology</topic><topic>Original Article</topic><topic>Protein Binding - drug effects</topic><topic>Random Allocation</topic><topic>receptors</topic><topic>Receptors, Dopamine D1 - metabolism</topic><topic>undereating</topic><topic>Veterinary Medicine/Veterinary Science</topic><topic>Zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zendehdel, Morteza</creatorcontrib><creatorcontrib>Hasani, Keyvan</creatorcontrib><creatorcontrib>Babapour, Vahab</creatorcontrib><creatorcontrib>Mortezaei, Sepideh Seyedali</creatorcontrib><creatorcontrib>Khoshbakht, Yalda</creatorcontrib><creatorcontrib>Hassanpour, Shahin</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zendehdel, Morteza</au><au>Hasani, Keyvan</au><au>Babapour, Vahab</au><au>Mortezaei, Sepideh Seyedali</au><au>Khoshbakht, Yalda</au><au>Hassanpour, Shahin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dopamine-induced hypophagia is mediated by D1 and 5HT-2c receptors in chicken</atitle><jtitle>Veterinary research communications</jtitle><stitle>Vet Res Commun</stitle><addtitle>Vet Res Commun</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>38</volume><issue>1</issue><spage>11</spage><epage>19</epage><pages>11-19</pages><issn>0165-7380</issn><eissn>1573-7446</eissn><abstract>The present study was designed to examine the effects of intracerebroventricular (ICV) injection of Dopamine (10, 20 and 40 nmol), L-DOPA (dopamine precursor; 62.5, 125 and 250 nmol), 6-OHDA (dopamine inhibitor; 75, 150 and 300 nmol), SCH 23390 (D₁ antagonist; 2.5, 5 and 10 nmol), AMI-193 (D₂ antagonist; 2.5, 5 and 10 nmol), NGB2904 (D₃ antagonist; 3.2, 6.4 and 12.8 nmol), L-741 T742 (D₄ antagonist; 1.5, 3 and 6 nmol) on food intake in FD₃ chickens. At following, birds were ICV injected using 8-OH-DPAT (5-HT₁A agonist; 15.25 nmol) and SB242084 (5-HT₂C antagonist; 1.5 μg) prior dopamine (40 nmol) injection. Cumulative food intake was determined until 3 h post-injection. According to the results, dopamine significantly decreased food intake in chickens (p < 0.05). The inhibitory effect of dopamine on food intake was decreased by SCH 23390 pretreatment (P < 0.05), but AMI-193, NGB2904 and L-741, 742 had no effect on food intake induced by dopamine. In addition, hypophagic effect of dopamine was attenuated by SB242084 (P < 0.05), but 8-OH-DPAT had no effect. These results suggest that dopamine decrease food intake via D₁ receptor and there is an interaction between dopaminergic and serotonergic systems via 5-HT₂C receptor in chickens.</abstract><cop>Dordrecht</cop><pub>Springer-Verlag</pub><pmid>24122738</pmid><doi>10.1007/s11259-013-9581-y</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals antagonists Biomedical and Life Sciences Chickens dopamine Dopamine - pharmacology Eating - drug effects food intake L-dopa Life Sciences Male Neurotransmitter Agents - pharmacology Original Article Protein Binding - drug effects Random Allocation receptors Receptors, Dopamine D1 - metabolism undereating Veterinary Medicine/Veterinary Science Zoology |
| title | Dopamine-induced hypophagia is mediated by D1 and 5HT-2c receptors in chicken |
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