Dopamine-induced hypophagia is mediated by D1 and 5HT-2c receptors in chicken

The present study was designed to examine the effects of intracerebroventricular (ICV) injection of Dopamine (10, 20 and 40 nmol), L-DOPA (dopamine precursor; 62.5, 125 and 250 nmol), 6-OHDA (dopamine inhibitor; 75, 150 and 300 nmol), SCH 23390 (D₁ antagonist; 2.5, 5 and 10 nmol), AMI-193 (D₂ antago...

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Veröffentlicht in:	Veterinary research communications 2014-03, Vol.38 (1), p.11-19
Hauptverfasser:	Zendehdel, Morteza, Hasani, Keyvan, Babapour, Vahab, Mortezaei, Sepideh Seyedali, Khoshbakht, Yalda, Hassanpour, Shahin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antagonists Biomedical and Life Sciences Chickens dopamine Dopamine - pharmacology Eating - drug effects food intake L-dopa Life Sciences Male Neurotransmitter Agents - pharmacology Original Article Protein Binding - drug effects Random Allocation receptors Receptors, Dopamine D1 - metabolism undereating Veterinary Medicine/Veterinary Science Zoology
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Zusammenfassung:	The present study was designed to examine the effects of intracerebroventricular (ICV) injection of Dopamine (10, 20 and 40 nmol), L-DOPA (dopamine precursor; 62.5, 125 and 250 nmol), 6-OHDA (dopamine inhibitor; 75, 150 and 300 nmol), SCH 23390 (D₁ antagonist; 2.5, 5 and 10 nmol), AMI-193 (D₂ antagonist; 2.5, 5 and 10 nmol), NGB2904 (D₃ antagonist; 3.2, 6.4 and 12.8 nmol), L-741 T742 (D₄ antagonist; 1.5, 3 and 6 nmol) on food intake in FD₃ chickens. At following, birds were ICV injected using 8-OH-DPAT (5-HT₁A agonist; 15.25 nmol) and SB242084 (5-HT₂C antagonist; 1.5 μg) prior dopamine (40 nmol) injection. Cumulative food intake was determined until 3 h post-injection. According to the results, dopamine significantly decreased food intake in chickens (p
ISSN:	0165-7380 1573-7446
DOI:	10.1007/s11259-013-9581-y