Recombinant DNA derived monomeric insulin analogue: Comparison with soluble human insulin in normal subjects

Recombinant DNA derived monomeric insulin analogue: Comparison with soluble human insulin in normal subjects

The authors compare the rate of absorption from subcutaneous tissue and the resulting hypoglycaemic effect of iodine-125 labelled soluble human insulin and a monomeric insulin analogue derived by recombinant DNA technology. The much faster absorption from subcutaneous tissue of the disubstituted mon...

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Veröffentlicht in:BMJ (Online) 1988-01, Vol.6658 (297), p.1236-1239
Hauptverfasser: Vora, J P, Owens, DR, Dolben, J, Atiea, JA, Dean, J D, Kang, S, Burch, A, Brange, J
Format: Artikel
Sprache:eng
Schlagworte:
DNA
man
recombinants
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Zusammenfassung:The authors compare the rate of absorption from subcutaneous tissue and the resulting hypoglycaemic effect of iodine-125 labelled soluble human insulin and a monomeric insulin analogue derived by recombinant DNA technology. The much faster absorption from subcutaneous tissue of the disubstituted monomeric insulin analogue compared with soluble insulin suggests that the analogue may be a potential candidate for rapid insulin delivery after subcutaneous bolus injection.
ISSN:0959-8138