Electrochemical behavior of propranolol hydrochloride in neutral solution on platinum nanoparticles doped multi-walled carbon nanotubes modified glassy carbon electrode

PtNPs/MWCNTs has been successfully stabilized onto the surface of GCE and used for electrochemical determination of PRO as a sensor. The results showed that the oxidation of PRO was catalyzed by PtNPs/MWCNTs film in neutral environment and that the peak potential of PRO was shifted to 1.10V. [Display omitted] ► Pt nanoparticles and multi-walled carbon nanotubes mixture as the electrode modified material. ► The modified material doped directly onto the electrode surface. ► Detected in the neutral environment. Platinum nanoparticles (PtNPs) were used in combination with multi-walled carbon nanotubes (MWCNTs) with Nafion as the adhesives for fabricating sensitivity-enhanced electrochemical propranolol hydrochloride (PRO) sensor. The modifier, PtNPs doped MWCNTs (PtNPs/MWCNTs), was characterized by transmission electron microscopy (TEM) and electrochemical method which showed an excellent character for electrocatalytic oxidization of PRO. In addition, the experimental parameters such as pH values, the concentration of PtNPs/MWCNTs and the scan rate were optimized. Due to the fine characteristics of PtNPs/MWCNTs, a good linear relationship between the anodic peak current and PRO concentration in the range 6.76×10−7–3.8×10−5M was observed. The detection limit of 8.45×10−8M was achieved with the linear correlation coefficient R=0.9965. The relative standard derivation was 2.74% for 3.38×10−6M PRO in 11 repeated determinations. This modified electrode showed excellent sensitivity and stability for the determination of PRO.