Iron-Catalyzed Oxidative Direct α‑C–H Bond Functionalization of Cyclic Ethers: Selective C–O Bond Formation in the Presence of a Labile Aldehyde Group

Iron-Catalyzed Oxidative Direct α‑C–H Bond Functionalization of Cyclic Ethers: Selective C–O Bond Formation in the Presence of a Labile Aldehyde Group

Iron catalyzed oxidative coupling of salicylaldehydes with cyclic ethers proceeded through the direct α-C–H functionalization of ethers, forming the corresponding acetals in moderate to excellent yields. This is the first example of iron catalyzed selective C–O bond formation in the presence of a se...

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Veröffentlicht in:Organic letters 2014-04, Vol.16 (7), p.1912-1915
Hauptverfasser: Barve, Balaji D, Wu, Yang-Chang, El-Shazly, Mohamed, Korinek, Michal, Cheng, Yuan-Bin, Wang, Jeh-Jeng, Chang, Fang-Rong
Format: Artikel
Sprache:eng
Schlagworte:
Acetals - chemistry
Aldehydes - chemistry
Catalysis
Ethers, Cyclic - chemistry
Iron - chemistry
Molecular Structure
Oxidation-Reduction
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Zusammenfassung:Iron catalyzed oxidative coupling of salicylaldehydes with cyclic ethers proceeded through the direct α-C–H functionalization of ethers, forming the corresponding acetals in moderate to excellent yields. This is the first example of iron catalyzed selective C–O bond formation in the presence of a sensitive aldehyde moiety.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol5004115