Synthesis of Naphthalene Amino Esters by the Blaise Reaction of o‑Alkynylarenenitriles
The action of a Reformatsky reagent on o-alkynylarenenitriles provides a convenient access to naphthalene amino esters via tandem 6-endo-dig carbannulation of in situ generated Blaise reaction intermediates. The products are formed in moderate to good yields with high chemo- and regioselectivity.
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| Veröffentlicht in: | Journal of organic chemistry 2014-04, Vol.79 (7), p.3244-3248 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | The action of a Reformatsky reagent on o-alkynylarenenitriles provides a convenient access to naphthalene amino esters via tandem 6-endo-dig carbannulation of in situ generated Blaise reaction intermediates. The products are formed in moderate to good yields with high chemo- and regioselectivity. |
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| ISSN: | 0022-3263 1520-6904 |
| DOI: | 10.1021/jo500137m |