Synthesis of Pyrroles from Terminal Alkynes, N‑Sulfonyl Azides, and Alkenyl Alkyl Ethers through 1‑Sulfonyl-1,2,3-triazoles

Synthesis of Pyrroles from Terminal Alkynes, N‑Sulfonyl Azides, and Alkenyl Alkyl Ethers through 1‑Sulfonyl-1,2,3-triazoles

A method for synthesis of substituted pyrroles has been developed. 1-Sulfonyl-1,2,3-triazoles generated from terminal alkynes gave α-imino rhodium carbene complexes, which when reacted with alkenyl alkyl ethers afforded substituted pyrroles. The method can be efficiently applied to a one-pot sequent...

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Veröffentlicht in:Organic letters 2014-04, Vol.16 (7), p.1900-1903
Hauptverfasser: Kim, Cheol-Eui, Park, Sangjune, Eom, Dahan, Seo, Boram, Lee, Phil Ho
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes - chemistry
Azides - chemistry
Catalysis
Combinatorial Chemistry Techniques
Ethers - chemistry
Molecular Structure
Pyrroles - chemical synthesis
Pyrroles - chemistry
Sulfones - chemical synthesis
Sulfones - chemistry
Triazoles - chemical synthesis
Triazoles - chemistry
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Zusammenfassung:A method for synthesis of substituted pyrroles has been developed. 1-Sulfonyl-1,2,3-triazoles generated from terminal alkynes gave α-imino rhodium carbene complexes, which when reacted with alkenyl alkyl ethers afforded substituted pyrroles. The method can be efficiently applied to a one-pot sequential reaction starting from terminal alkynes.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol500718s