Feasibility of macrophage mediated on-demand drug release from surface eroding poly(ethylene carbonate)

Macrophage induced surface degradation of poly(ethylene carbonate) (PEC) was investigated under in vitro conditions. Degradation of PEC with the MW of 41kDa (PEC41) was slower than that of PEC with the MW of 200kDa (PEC200). In terms of macrophage mediated drug release from PEC matrix, in cell-free...

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Veröffentlicht in:	International journal of pharmaceutics 2014-04, Vol.465 (1-2), p.1-4
Hauptverfasser:	Chu, Dafeng, Beck-Broichsitter, Moritz, Curdy, Catherine, Riebesehl, Bernd, Kissel, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biodegradable polymers Cell Line Chemistry, Pharmaceutical Delayed-Action Preparations Drug Carriers Drug delivery systems Feasibility Studies Kinetics Levofloxacin Levofloxacin - chemistry Macrophages Macrophages - metabolism Mice Molecular Weight Poly(ethylene carbonate) Polyethylenes - chemistry Solubility Surface degradation Surface Properties
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