Feasibility of macrophage mediated on-demand drug release from surface eroding poly(ethylene carbonate)

Feasibility of macrophage mediated on-demand drug release from surface eroding poly(ethylene carbonate)

Macrophage induced surface degradation of poly(ethylene carbonate) (PEC) was investigated under in vitro conditions. Degradation of PEC with the MW of 41kDa (PEC41) was slower than that of PEC with the MW of 200kDa (PEC200). In terms of macrophage mediated drug release from PEC matrix, in cell-free...

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Veröffentlicht in:International journal of pharmaceutics 2014-04, Vol.465 (1-2), p.1-4
Hauptverfasser: Chu, Dafeng, Beck-Broichsitter, Moritz, Curdy, Catherine, Riebesehl, Bernd, Kissel, Thomas
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biodegradable polymers
Cell Line
Chemistry, Pharmaceutical
Delayed-Action Preparations
Drug Carriers
Drug delivery systems
Feasibility Studies
Kinetics
Levofloxacin
Levofloxacin - chemistry
Macrophages
Macrophages - metabolism
Mice
Molecular Weight
Poly(ethylene carbonate)
Polyethylenes - chemistry
Solubility
Surface degradation
Surface Properties
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Zusammenfassung:Macrophage induced surface degradation of poly(ethylene carbonate) (PEC) was investigated under in vitro conditions. Degradation of PEC with the MW of 41kDa (PEC41) was slower than that of PEC with the MW of 200kDa (PEC200). In terms of macrophage mediated drug release from PEC matrix, in cell-free medium, less than 1% of levofloxacin was released from both PEC samples in 10 days, while more than 60 and 20% of the drug, levofloxacin, can be detected in medium with macrophages from PEC200 and PEC41 films, respectively. This work indicated that on-demand drug delivery induced by macrophages can be achieved with PEC polymer.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2014.02.005