Anti-pyretic and Antiplasmodial Activities of a Polyherbal Formula (Joloo)

To investigate the polyherbal formula (Joloo) for its antimalarial and anti-pyretic properties on mice and rats. In the antimalarial study, mice were infected with Plasmodium berghei using three doses. Pyrexia was induced in the rats by the administration of 10 mg kg-1 b.wt., of 2,4-Dinitrophenol intraperitoneally, while measurement was by inserting a clinical thermometer into their anal cavities for about 2 min. Chloroquine and acetylsalicylic acid were used as reference drugs in mice and rats respectively, while water served as control for both. In the anti-pyretic study, Joloo significantly reduced hyperthermia in rats dose-dependently. This clearly suggests that Joloo contain biologically active substances with the potential of managing and treating malaria and fever. It provides scientific evidence to support the isolation and development of biologically active components as anti-malarial and antipyretic agents.