Semiquinone derivative isolated from Bacillus sp. INM-1 protects cellular antioxidant enzymes from γ-radiation-induced renal toxicity

This study was focused to evaluate protection of indigenous antioxidant system of mice against gamma radiation-induced oxidative stress using a semiquinone (SQGD)-rich fraction isolated from Bacillus sp. INM-1. Male C57bl/6 mice were administered SQGD (50 mg/kgb.w.i.p.) 2 h before irradiation (10 Gy...

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Veröffentlicht in:	Molecular and cellular biochemistry 2013-07, Vol.379 (1-2), p.19-27
Hauptverfasser:	Mishra, S., Reddy, D. S. K., Jamwal, V. S., Bansal, D. D., Patel, D. D., Malhotra, P., Gupta, A. K., Singh, P. K., Jawed, S., Kumar, Raj
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Bacillus Bacillus - chemistry Benzoquinones - pharmacology Benzoquinones - therapeutic use Biochemistry Biomedical and Life Sciences Cardiology Catalase - metabolism Free Radical Scavengers - metabolism Gamma rays Glutathione - metabolism Glutathione transferase Glutathione Transferase - metabolism Kidney - drug effects Kidney - enzymology Kidney - radiation effects Life Sciences Male Medical Biochemistry Mice Mice, Inbred C57BL Nuclear radiation Oncology Oxidative Stress Quinone Radiation Injuries, Experimental - enzymology Radiation Injuries, Experimental - prevention & control Radiation-Protective Agents - pharmacology Radiation-Protective Agents - therapeutic use Superoxide Superoxide Dismutase - metabolism
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Zusammenfassung:	This study was focused to evaluate protection of indigenous antioxidant system of mice against gamma radiation-induced oxidative stress using a semiquinone (SQGD)-rich fraction isolated from Bacillus sp. INM-1. Male C57bl/6 mice were administered SQGD (50 mg/kgb.w.i.p.) 2 h before irradiation (10 Gy) and modulation in antioxidant enzymes activities was estimated at different time intervals and compared with irradiated mice which were not pretreated by SQGD. Compared to untreated controls, SQGD pretreatment significantly ( p
ISSN:	0300-8177 1573-4919
DOI:	10.1007/s11010-013-1622-x