Antiviral activity of gyrase inhibitors norfloxacin, coumermycin A sub(1) and nalidixic acid

Antiviral activity of gyrase inhibitors norfloxacin, coumermycin A sub(1) and nalidixic acid

The quinolone and coumarin antibiotics are well known inhibitors of bacterial DNA gyrase. This enzyme is a topoisomerase II which is capable of introducing negative supercoils into a relaxed DNA molecule. The authors aim was to test the possible activity of these drugs as antiviral agents and to gai...

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Hauptverfasser: Ferrazzi, E, Peracchi, M, Biasolo, MA, Faggionato, O, Stefanelli, S, Palu, G
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creator Ferrazzi, E
Peracchi, M
Biasolo, MA
Faggionato, O
Stefanelli, S
Palu, G
description The quinolone and coumarin antibiotics are well known inhibitors of bacterial DNA gyrase. This enzyme is a topoisomerase II which is capable of introducing negative supercoils into a relaxed DNA molecule. The authors aim was to test the possible activity of these drugs as antiviral agents and to gain insight into their mechanism of action.
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title Antiviral activity of gyrase inhibitors norfloxacin, coumermycin A sub(1) and nalidixic acid
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