Antiviral activity of gyrase inhibitors norfloxacin, coumermycin A sub(1) and nalidixic acid

Antiviral activity of gyrase inhibitors norfloxacin, coumermycin A sub(1) and nalidixic acid

The quinolone and coumarin antibiotics are well known inhibitors of bacterial DNA gyrase. This enzyme is a topoisomerase II which is capable of introducing negative supercoils into a relaxed DNA molecule. The authors aim was to test the possible activity of these drugs as antiviral agents and to gai...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Ferrazzi, E, Peracchi, M, Biasolo, MA, Faggionato, O, Stefanelli, S, Palu, G
Format: Tagungsbericht
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The quinolone and coumarin antibiotics are well known inhibitors of bacterial DNA gyrase. This enzyme is a topoisomerase II which is capable of introducing negative supercoils into a relaxed DNA molecule. The authors aim was to test the possible activity of these drugs as antiviral agents and to gain insight into their mechanism of action.
ISSN:0006-2952